5776-45-4

Usage

Uses

Used in Pharmaceutical Industry:
Estradiol 17-Palmitate is used as a hormone replacement therapy for [application reason] to alleviate symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness. It also helps in maintaining bone density and reducing the risk of osteoporosis.
Used in Cosmetic Industry:
Estradiol 17-Palmitate is used as an ingredient in anti-aging skincare products for [application reason] its ability to improve skin elasticity, reduce wrinkles, and promote a more youthful appearance.
Used in Research and Development:
Estradiol 17-Palmitate is used as a research compound for [application reason] studying the effects of estrogen on various physiological processes and the development of new drugs targeting estrogen-related conditions.
Used in Fertility Treatments:
Estradiol 17-Palmitate is used as a component in fertility treatments for [application reason] its role in regulating the menstrual cycle and promoting the development of ovarian follicles.

Upstream product

• 50-28-2 estradiol 
• 112-67-4 n-hexadecanoyl chloride 
• 63042-27-3 3.17β-dipalmitoyloxy-estratriene-(1.3.5(10)) 

Relevant academic research and scientific papers

Rapid synthesis of long chain fatty acid esters of steroids in ionic liquids with microwave irradiation: Expedient one-pot procedure for estradiol monoesters

We report the rapid synthesis (1 min) in high yield of fatty acid ester (FAE) derivatives of several steroids under microwave irradiation in an ionic liquid (IL). An expedient regioselective hydrolysis at C-3 of estradiol diesters is also reported.

Mass Spectrometric Studies on 17β-Estradiol-17-fatty Acid Esters: Evidence for the Formation of Anion-Dipole Intermediates

The behaviour towards low collision energy processes (eV range) of (1-) prepared under negative ion chemical ionization (NICI) ammonia conditions from 17β-estradiol-17-fatty acid esters has been investigated.From such bifunctional compounds containing two acidic sites (i.e. phenol and ester groups), two isomeric forms (i.e. phenoxide and enolate forms) characterize the (1-) ion structures, whose distribution depends on the ion preparation mode.Here NICI (ammonia) provides both phenoxide and enolate forms as the (1-) species.This behaviour contrasts with the regioselectivity observed for proton abstraction from phenol under NICI (N2O) and fast atom bombardment conditions.Production of both phenoxide and enolate forms in NICI (ammonia) is demonstrated under NICI (ND3) conditions in which DO-labelled d - H>(1-) enolate ions are produced in a similar yield to unlabelled d - D>(1-) phenoxide ions.Collisionally activated dissociation (CAD) spectra of both isomeric deprotonated molecules differ strongly by the presence of two different pairs of complementary daughter ions, suggesting that these ionic species are unconvertible.This is due to a steric hindrance effect on the long-distance proton transfer.A mechanistic investigation on the formation of fragment ion pairs produced under CAD was performed with various deuterium-labelled molecules.From these experiments, evidence is provided for molecular isomerizations into ion-dipole complexes (prior to dissociation) which are structurally dependent on the initial charge location.Direct dissociation of these intermediates competes with the occurence of exothermic proton transfer(s) yielding the formation of other isomeric intermediate forms.The orientation of these proton transfers is dictated by the relative acidities of both moieties of the complex.