57761-80-5Relevant articles and documents
A novel highly stereoselective synthesis of 2,3-disubstituted 3H-quinazoline-4-one derivatives
Zhichkin, Paul,Kesicki, Edward,Treiberg, Jennifer,Bourdon, Lisa,Ronsheim, Matthew,Ooi, Hua Chee,White, Stephen,Judkins, Angela,Fairfax, David
, p. 1415 - 1418 (2007/10/03)
Figure presented An efficient three-step synthesis of chiral 3H-quinazoline-4-one derivatives from commercial materials is disclosed. The Mumm reaction of imidoyl chloride with α-amino acids followed by reductive cyclization affords enantiomerically pure (ee >93%) quinazoline-4-ones in good overall yield. A comparison with existing approaches indicates that this method is superior for hindered substrates.