57769-48-9Relevant academic research and scientific papers
Late-stage construction of stapled peptides through Fujiwara-Moritani reaction between tryptophan and olefins
Liu, Jiang,Lu, Qi,Wang, Peng,Zeng, Wei,Zhu, Qing
supporting information, p. 11661 - 11664 (2021/11/12)
Herein, the first example of a palladium-catalyzed Fujiwara-Moritani reaction for olefination of tryptophan (Trp) residues, free from directing groups, was presented. The developed reaction proceeds efficiently for peptide modification, ligation and pepti
Preparation method of trifluoromethylated polypeptide compound
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Paragraph 0041; 0043, (2020/12/30)
The invention discloses a preparation method of a trifluoromethylated polypeptide compound shown as a formula (II). The method comprises the following steps: by using a mixed solvent of DMF and waterin a volume ratio of 1:(1-4) as a reaction medium, reacting a polypeptide compound shown as a formula (I) with 1-(trifluoromethyl)-1,2-benziodoxol-3(1H)-one in the presence of a photocatalyst at roomtemperature under blue light for 3-8 hours, and after the reaction is completed, carrying out post-treatment on the obtained reaction mixture to obtain the trifluoromethylated polypeptide compound asshown in the formula (II). According to the method, the reaction is driven to be carried out under the irradiation of visible light, the reaction solvent is a mixed solvent of DMF and water, the greenchemical concept is better met, the product can be prepared in one step, the operation process is simple, raw material sources are commercialized and easy to obtain, the photocatalyst is utilized, good catalytic performance is achieved, the reaction condition is mild, and the site selectivity is high.
CONTINUOUS, SOLVENT-FREE AND NON-ENZYMATIC PEPTIDE SYNTHESIS BY REACTIVE EXTRUSION
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Page/Page column 32; 33, (2019/09/04)
The present disclosure relates to A a continuous, solvent-free and non-enzymatic method for synthesizing a compound of formula (I): Ra-POLYPEP-Rc (I) wherein: POLYPEP is a poly-amino acid compound, Ra and Rc are as specified in the disclosure, which method comprises the steps of: a) feeding an extrusion reactor with (1) a compound of formula (II) Ra-PEPNt-Rg (II) wherein; PEPNt is a mono- or a poly-aminoacid compound, Ra and Rg are as specified in the disclosure, and (2) a compound of formula (III) H-PEPCt-Rc (III) wherein: PEPCt is a mono- or a poly-amino acid compound, and Rc is as defined in the disclosure in the absence of any solvent, so that the compound of formula (II) and the compound of formula (III) react together for generating a compound of formula (I), and b) collecting the compound of formula (I) from the extrusion reactor.
Total synthesis of argyrins A and e
Wu, Wenbin,Li, Zheng,Zhou, Guangbiao,Jiang, Sheng
supporting information; experimental part, p. 2488 - 2491 (2011/05/09)
The total synthesis of argyrins A and E were accomplished using a convergent strategy by condensation of one tripeptide and two dipeptide fragments. The synthesis strategy, which was developed for the protection of peptide fragments and identification of the optimum macrocylization site, can be applied to further synthetic studies involving other members of the argyrin family.
