57772-75-5Relevant academic research and scientific papers
New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3
Stefane, Bogdan,Brozic, Petra,Vehovc, Matej,Rizner, Tea Lanisnik,Gobec, Stanislav
, p. 2563 - 2571 (2009)
A series of cyclopentane derivatives was synthesized and evaluated for inhibition of the steroid metabolizing enzymes AKR1C1 and AKR1C3. Selective inhibitors that are active in the low micromolar range were identified. These compounds represent promising starting points in the development of new anticancer agents for the treatment of hormone-dependent forms of cancer and other diseases where AKR1C1 and AKR1C3 are involved.
Visible Light Photoredox-Catalyzed Arylative Ring Expansion of 1-(1-Arylvinyl)cyclobutanol Derivatives
Kwon, Su Jin,Kim, Dae Young
, p. 4562 - 4565 (2016)
A visible light mediated photocatalytic arylation/ring expansion of alkenylcyclobutanols has been developed. This approach provides a mild and operationally simple access to the synthesis of functionalized cyclic ketones from the coupling reaction of alke
Reactivity of Lithium β-Ketocarboxylates: The Role of Lithium Salts
Berton, Mateo,Mello, Rossella,Williard, Paul G.,González-Nú?ez, María Elena
supporting information, p. 17414 - 17420 (2017/12/15)
Lithium β-ketocarboxylates 1(COOLi), prepared by the reaction of lithium enolates 2(Li+) with carbon dioxide, readily undergo decarboxylative disproportionation in THF solution unless in the presence of lithium salts, in which case they are indefinitely stable at room temperature in inert atmosphere. The availability of stable THF solutions of lithium β-ketocarboxylates 1(COOLi) in the absence of carbon dioxide allowed reactions to take place with nitrogen bases and alkyl halides 3 to give α-alkyl ketones 1(R) after acidic hydrolysis. The sequence thus represents the use of carbon dioxide as a removable directing group for the selective monoalkylation of lithium enolates 2(Li+). The roles of lithium salts in preventing the disproportionation of lithium β-ketocarboxylates 1(COOLi) and in determining the course of the reaction with bases and alkyl halides 3 are discussed.
Dual visible light photoredox and gold-catalyzed arylative ring expansion
Shu, Xing-Zhong,Zhang, Miao,He, Ying,Frei, Heinz,Toste, F. Dean
, p. 5844 - 5847 (2014/05/20)
A combination of visible light photocatalysis and gold catalysis is applied to a ring expansion-oxidative arylation reaction. The reaction provides an entry into functionalized cyclic ketones from the coupling reaction of alkenyl and allenyl cycloalkanols with aryl diazonium salts. A mechanism involving generation of an electrophilic gold(III)-aryl intermediate is proposed on the basis of mechanistic studies, including time-resolved FT-IR spectroscopy.
