577778-42-8Relevant academic research and scientific papers
4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs
Manetti, Dina,Martini, Elisabetta,Ghelardini, Carla,Dei, Silvia,Galeotti, Nicoletta,Guandalini, Luca,Romanelli, Maria Novella,Scapecchi, Serena,Teodori, Elisabetta,Bartolini, Alessandro,Gualtieri, Fulvio
, p. 2303 - 2306 (2007/10/03)
Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-aminopiperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9, active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease.
