577778-48-4

Basic information

• Product Name: Benzonitrile, 2-(2-methylpropoxy)-5-[5-(4-pyridinyl)-1H-1,2,4-triazol-3-yl]-
• CAS NO: 577778-48-4
• Molecular Formula: C18H17N5O
• Molecular Weight: 319.366
• Mol File: 577778-48-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 2-(2-methylpropoxy)-5-[5-(4-pyridinyl)-1H-1,2,4-triazol-3-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 2-(2-methylpropoxy)-5-[5-(4-pyridinyl)-1H-1,2,4-triazol-3-yl]-(577778-48-4)
• EPA Substance Registry System: Benzonitrile, 2-(2-methylpropoxy)-5-[5-(4-pyridinyl)-1H-1,2,4-triazol-3-yl]-(577778-48-4)

Safety Data

• Hazardous Substances Data: 577778-48-4(Hazardous Substances Data)

Upstream product

• 54-85-3 isoniazid 
• 161718-81-6 4-isobutoxyisophthalonitrile 

Relevant articles and documents

Discovery of 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, FYX-051-a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia

Our previous study identified 2-[2-(2-methoxy-ethoxy)-ethoxy]-5-[5-(2-methyl-4-pyridyl)-1H-[1,2,4]triazol-3-yl]-benzonitrile (2) as a safe and potent xanthine oxidoreductase (XOR) inhibitor for the treatment of hyperuricemia. Here, we synthesized a series of 3,5-dipyridyl-1,2,4-triazole derivatives and, in particular, examined their in vivo activity in lowering the serum uric acid levels in rats. As a result, we identified 3-(3-cyano-4-pyridyl)-5-(4-pyridyl)-1,2,4-triazole (FYX-051, compound 39) to be one of the most potent XOR inhibitors; it exhibited an extremely potent in vivo activity, weak CYP3A4-inhibitory activity and a better pharmacokinetic profile than compound 2. Compound 39 is currently being evaluated in a phase 2 clinical trial.