5779-62-4

Usage

Uses

Used in Dietary Supplements:
Sitosterol is used as a dietary supplement for individuals with high cholesterol levels or those at risk for cardiovascular disease. It functions by inhibiting the absorption of cholesterol in the intestines, thereby reducing levels of low-density lipoprotein (LDL) or "bad" cholesterol in the bloodstream.
Used in Cardiovascular Health:
Sitosterol is utilized in cardiovascular health applications due to its cholesterol-lowering effects. By reducing LDL cholesterol levels, it can potentially decrease the risk of heart disease and other cardiovascular conditions.
Used in Anti-Inflammatory and Antioxidant Therapies:
Leveraging its anti-inflammatory and antioxidant properties, sitosterol is applied in therapies aimed at reducing inflammation and oxidative stress, which are implicated in various diseases and aging processes.
Used in Prostate Health:
Sitosterol is used in prostate health applications, being researched for its potential role in reducing symptoms of benign prostatic hyperplasia (enlarged prostate) and supporting overall prostate health.

Upstream product

• 106351-00-2 (3S,8S,9S,10R,13R,14S,17R)-17-((1R,4S)-4-Ethyl-1,5-dimethyl-hexyl)-3-methoxymethoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene 
• 83787-27-3 (22R,23Z)-6β-methoxy-26-nor-3α,5-cyclo-5α-cholest-23-en-22-ol 
• 83787-24-0 (22R)-6β-methoxy-3α,5-cyclo-27-nor-5α-cholest-23-yn-22-ol 
• 106350-99-6 C₃₅H₅₈O₄S₄ 
• 106401-65-4 (4S,6S)-4-Ethyl-6-[(S)-1-((3S,8S,9S,10R,13S,14S,17R)-3-methoxymethoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-methyl-tetrahydro-pyran-2-one 
• 106350-92-9 Bromo-acetic acid (S)-1-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-3-oxo-pentyl ester 
• 106401-66-5 (3S,5S,6S)-3-Ethyl-6-((3S,8S,9S,10R,13S,14S,17R)-3-methoxymethoxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methyl-heptane-1,5-diol 
• 106401-64-3 (4S,6S)-4-Ethyl-6-[(S)-1-((3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-ethyl]-3-methyl-tetrahydro-pyran-2-one 
• 106401-63-2 (4S,6S)-4-Ethyl-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-3-methyl-tetrahydro-pyran-2-one 
• 106350-94-1 (4S,6S)-4-Ethyl-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-tetrahydro-pyran-2-one 
• 106350-93-0 (22S)-6β-methoxy-27-nor-3α,5-cyclo-5α-stigmast-24-en-26,22-lactone 
• 106350-86-1 (2S,3S)-1-(2-Ethyl-[1,3]dithian-2-yl)-3-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-butan-2-ol 
• 106350-89-4 (22S)-22-hydroxy-6β-methoxy-27-nor-3α,5-cyclo-5α-cholestan-24-one 
• 54604-91-0 2-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-oxirane 

Downstream Products

• 18777-86-1 clionasterol benzoate 
• 67978-97-6 3β-phenylcarbamoyloxy-24α_FH-stigmastene-(5) 
• 1065-41-4 O-(3.5-dinitro-benzoyl)-clionasterol 
• 87100-47-8 4-(4-Undecyl-benzoyl)-benzoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((1R,4S)-4-ethyl-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 105819-23-6 24α_FH-stigmast-4-en-3-one-(2,4-dinitro-phenylhydrazone) 
• 80860-62-4 C₅₇H₇₈O₇ 
• 897-06-3 Androsta-1,4-diene-3,17-dione 
• 71154-85-3 23,24-Bisnorchola-1,4-dien-3-on-22-oic acid 
• 80860-62-4 C₅₇H₇₈O₇ 
• 23671-20-7 stigmast-4-en-3,6-dione 
• 2034-72-2 poriferasta-3,5-dien-7-one 

Relevant academic research and scientific papers

Process for recovery of plant sterols from by-product of vegetable oil refining

The process for recovery of plant sterols and tocopherols from deodorization distillates formed during chemical or physical refining of vegetable oils consists of the following steps: free fatty acids are removed from the deodorization distillate by vacuum distillation or by continuation solvent saponification, after the removal of free fatty acids, the received material is reacted with an aromatic carboxylic acid anhydride at a temperature of 50-150° C., under reduced pressure, after the treatment with anhydride, tocopherols are removed from the mixture, and crystalline free sterols are recovered from the distillation residue containing sterol esters, di- and triglycerides by transesterification.

Stereochemistry in the Hydrogenation of Steroidal (22R)- and (22S)-Δ24-26,22-Lactones

Catalytic hydrogenation of the (22R)-unsaturated lactone 8 and its (22S)-epimer 9 afforded stereoselectively the (22R,24R)-saturated lactone 10 and the (22S,24S)-isomer 11, respectively.The C-24 stereochemistry of the hydrogenated products was determined by their conversion into 24-ethylcholesterols.Keywords - stereoselective hydrogenation; stereoidal lactone; sitosterol; clionasterol

Side Chain Structural Requirement for Utilization of Sterols by the Silkworm for Growth and Development. Non-stereoselective Utilization of the 24-Stereoisomeric Pairs of 24-Alkylsterols

Four C-24 epimeric pairs of 24-alkylsterols 1-8 were stereoselectively synthesized via orthoester Claisen rearrangement of the (22)R or (22S)-Δ23Z steroid derivatives (11 and 12).These compounds were tested on the silkworm larvae, Bombyx mori, in order to examine the relationship of the C-24 stereochemical arrangement and utilizability as a nutrient sterol.All of the tested sterols effectively supported the growth and development of the insect and were converted into cholesterol regardless of the C-24 configuration.Keywords - 24-alkylcholesterol; 24-alkyl-22-dehydrocholesterol; orthoester Claisen rearrangement; stereoselective synthesis; insect sterol; silkworm

Triterpene constituents of Tabernaemontana laurifolia and Haplophyton cimicidum

The triterpene bauerenyl acetate was isolated directly by crystallization from the non-polar neutral extract of the bark of Tabernaemontana laurifolia D.C. A similar extract of Haplophyton cimicidum (whole plant) yielded, after chromatography, the triterpenes erythrodiol monostearate, bauerenol and betulin, as well as the steroid β-sitosterol.