23671-20-7

Basic information

• Product Name: stigmast-4-ene-3,6-dione
• Synonyms: stigmasta-4-ene-3,6-dione
• CAS NO: 23671-20-7
• Molecular Formula: C₂₉H₄₆O₂
• Molecular Weight: 426.6743
• Mol File: 23671-20-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 523.4°C at 760 mmHg
• Flash Point: 192.8°C
• Density: 1.01g/cm³
• Vapor Pressure: 4.73E-11mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: stigmast-4-ene-3,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: stigmast-4-ene-3,6-dione(23671-20-7)
• EPA Substance Registry System: stigmast-4-ene-3,6-dione(23671-20-7)

Safety Data

• Hazardous Substances Data: 23671-20-7(Hazardous Substances Data)

Upstream product

• 83-46-5 β-sitosterol 
• 64-19-7 acetic acid 
• 74395-55-4 5α-stigmastane-5-ol-3,6-dione 
• 141610-97-1 (24S)-24-ethylcholesta-3β,5α,6β-triol 
• 83-46-5 clionasterol 
• 6035-62-7 (10R)-3c-Acetoxy-10r.13c-dimethyl-17c-((R)-1-methyl-4-isopropyl-hexen-(4t)-yl)-(8cH.9tH.14tH)-Δ⁵-tetradecahydro-1H-cyclopenta[a]phenanthren 
• 16137-56-7 3,5,6-trihydroxysitostane 
• 7647-01-0 hydrogenchloride 
• 67-66-3 chloroform 
• 74395-55-4 (24R)-24-ethyl-5α-cholestan-5-ol-3,6-dione 
• 67-56-1 methanol 

Downstream Products

• 77551-74-7 stigmastan-3,6-dione 
• 115249-27-9 3-oxo-2'-phenyl-4-stigmasteno<4,6-cd>pyrazole 

Relevant articles and documents

A STEROID FROM CALOTROPIS PROCERA

Procesterol, a new steroidal hydroxy ketone, has been isolated from the fresh and undried flowers of Calotropis procera.The chemical and spectral studies identified it as a C-6, C-24 diepimer of stigmast-4-en-6β-ol-3-one.Key Word Index - Calotropis procera; Asclepiadaceae; procesterol; hydroxyketone; (24S)-24-ethyl stigmast-4-en-6β-ol-3-one.

Sterol derivatives and its preparation method and application

The invention discloses a sterol derivative of beta-sitosterol, beta-stigmasterol and cholesterol, and is shown as a formula VI. The invention also discloses a preparation method of the sterol derivative. The invention also discloses application of the sterol derivative to the aspect of preparation of wound healing promoting medicine. By starting from easily obtained natural products, the beta-sitosterol, the beta-stigmasterol and the cholesterol are used as starting raw materials; the synthetic method is simple; better operability and reaction yield are realized. The prepared sterol derivative has the obvious wound healing promoting activity; the multiplication, migration and collagen synthesis capability on L929 mechanocytes is obviously higher than that of the raw material and positive control medicine recombinant human bFGF (basic fibroblast growth factor). Compared with protide type medicine (such as bFGF), the prepared sterol derivative has more diversified dosage forms and medication modes; the reference is provided for the application in the field of wound healing promoting. The formula VI is shown as the accompanying diagram.

Synthesis and evaluation of some steroidal oximes as cytotoxic agents: Structure/activity studies (I)

The side chain of a compound plays an important role in its biological function. In our studies, we have found that hydroximinosteroid derivatives with different side chains and position of hydroximino on ring A and B displayed remarkable distinct cytotoxicities against a diversity of cancer cell types. Presence of an oxime group on ring B and a hydroxy on ring A or B resulted in a higher cytotoxicity than other structural motifs. In addition, a cholesterol-type side chain at position 17 was required for the biological activity. Our findings provide new evidence showing the relationship between the chemical structure and biological function. The information obtained from the studies may be useful for the design of novel chemotherapeutic drugs.