577992-83-7Relevant academic research and scientific papers
Pd-Xantphos-catalyzed direct arylation of nucleosides
Ngassa, Felix N.,DeKorver, Kyle A.,Melistas, Theothora S.,Yen, Edmund A.-H.,Lakshman, Mahesh K.
, p. 4613 - 4616 (2006)
Direct arylation of the exocyclic amino groups of nucleosides represents a simple approach to N-aryl nucleoside derivatives. To date, one limitation has been that only electron-deficient aryl bromides and triflates possessed adequate reactivity for effici
Synthesis of N2 2'-deoxyguanosine adducts formed by 1-nitropyrene.
Chakraborti, Debasis,Colis, Laureen,Schneider, Renee,Basu, Ashis K
, p. 2861 - 2864 (2007/10/03)
[reaction: see text] Synthesis of N(2) 2'-deoxyguanosine adducts formed by the ubiquitous carcinogen, 1-nitropyrene, is reported. Various conditions of Buchwald-Hartwig palladium-catalyzed amination are examined. The most convenient synthetic approach inv
Synthesis of pyrene and benzo[a]pyrene adducts at the exocyclic amino groups of 2′-deoxyadenosine and 2′-deoxyguanosine by a palladium-mediated C - N bond-formation strategy
Lakshman, Mahesh K.,Ngassa, Felix N.,Bae, Suyeal,Buchanan, Dennis G.,Hahn, Hoh-Gyu,Mah, Heduck
, p. 6020 - 6030 (2007/10/03)
Single-electron oxidation of the carcinogenic hydrocarbon benzo[a]pyrene (BaP) is thought to result in a radical cation intermediate and this species has been proposed to cause alkylation at the nitrogens of the purine nucleobases. Although several differ
