578020-35-6Relevant articles and documents
Enzyme-mediated preparation of chiral 1,3-dioxane odorants
Abate, Agnese,Brenna, Elisabetta,Fronza, Giovanni,Fuganti, Claudio,Ronzani, Sabrina,Serra, Stefano
, p. 592 - 606 (2003)
The enantiomerically enriched diastereoisomers of the chiral 1,3-dioxane odorants Floropal (1) and Magnolan (2) were prepared by an enzyme-mediated approach. Their olfactory properties were evaluated to investigate differences in the odor perception for the stereoisomers.
Stereoselective addition of organometallic reagents to β-hydroxyketones
Garcia Ruano, Jose Luis,Tito, Amelia,Culebras, Rafael
, p. 2177 - 2186 (2007/10/03)
Reactions of several β-hydroxyketones with different methylation reagents are reported. The de's are moderated or good (40-75%) and slightly change with the relative steric size of the R groups at the starting hydroxyketone. The syn-diols are predominant in reactions with Me3Al/ZnBr2 and MeLi/Me3Al, whereas the anti-diols are the major ones with MeLi/ZnBr2. The method has been used to synthesize optically pure (+)-(2R,4R)-2-phenyl-2,4-pentanediol.