57817-55-7

Basic information

• Product Name: 6-BROMOHEXANEAMIDE
• Synonyms: 6-BROMOCAPROAMIDE;6-BROMOHEXANEAMIDE;6-Bromohexanamide
• CAS NO: 57817-55-7
• Molecular Formula: C₆H₁₂BrNO
• Molecular Weight: 194.07
• Mol File: 57817-55-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 104-106°C
• Boiling Point: 325.8 °C at 760 mmHg
• Flash Point: 150.8 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0.000225mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 16.57±0.40(Predicted)
• CAS DataBase Reference: 6-BROMOHEXANEAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMOHEXANEAMIDE(57817-55-7)
• EPA Substance Registry System: 6-BROMOHEXANEAMIDE(57817-55-7)

Safety Data

• Hazard Codes: Xi,C
• HazardClass: IRRITANT
• Hazardous Substances Data: 57817-55-7(Hazardous Substances Data)

Usage

General Description

6-BromoHexanamide is a chemical compound with a molecular formula of C6H12BrNO. It belongs to the category of an organic compound known as carboximidic acids, characterized by an imino group attached to two acyl groups. It is often used in various organic synthesis processes due to its reactivity. It’s characterized by a combination of bromine, carbon, hydrogen, nitrogen, and oxygen atoms. Safety measures must be observed when handling, as it may cause skin and eye irritation, and could be harmful if inhaled or swallowed.

InChI:InChI=1/C6H12BrNO/c7-5-3-1-2-4-6(8)9/h1-5H2,(H2,8,9)

Upstream product

• 61739-32-0 C₉H₁₃BrN₂O 
• 4224-70-8 6-bromohexanoic acid 
• 151823-76-6 C₉H₁₅BrO₄ 
• 22809-37-6 6-bromohexanoyl chloride 
• 137936-43-7 6-methoxyhexanenitrile 

Downstream Products

• 6621-59-6 6-bromo-1-hexanenitrile 
• 188727-13-1 6'-(4-mercapto-1-phenylpyrazolo[3,4-d]pyrimidin-6-ylthio)hexanamide 
• 72224-28-3 6-(4-phenyl-piperazin-1-yl)-hexanoic acid amide 
• 1246816-76-1 5-bromopentylammonium chloride 

Relevant articles and documents

Synthesis and evaluation of novel ellipticines as potential anti-cancer agents

Drugs that inhibit DNA topoisomerase I and DNA topoisomerase II have been widely used in cancer chemotherapy. We report herein the results of a focused medicinal chemistry effort around novel ellipticinium salts which target topoisomerase I and II enzymes with improved solubility. The salts were prepared by reaction of ellipticine with the required alkyl halide and evaluated for DNA intercalation, topoisomerase inhibition and growth inhibition against 12 cancer cell lines. Results from the topoisomerase I relaxation assay indicated that all novel ellipticine derivatives behaved as intercalating agents. At a concentration of 100 μM, specific topoisomerase I inhibition was not observed. Two of the derivatives under investigation were found to fully inhibit the DNA decatenation reaction at a concentration of 100 μM, indicative of topoisomerase II inhibition. N-Alkylation of ellipticine was found to enhance the observed growth inhibition across all cell lines and induce growth inhibition comparable to that of Irinotecan (CPT-11; GI50 1-18 μM) and in some cell lines better than Etoposide (VP-16; GI50 = 0.04-5.2 μM). 6-Methylellipticine was the most potent growth inhibitory compound assessed (GI50 = 0.47-0.9 μM). N-Alkylation of 6-methylellipticine was found to reduce this response with GI50 values in the range of 1.3-28 μM.

Hydrosilanes are not always reducing agents for carbonyl compounds but can also induce dehydration: A ruthenium-catalyzed conversion of primary amides to nitriles

A practical procedure for production of nitriles is offered by the triruthenium carbonyl cluster catalyzed dehydration of primary carboxamides with hydrosilanes under neutral conditions. This is the first example that a transition-metal-catalyzed activation of Si-H bonds does not lead to the reduction of carbonyl compounds but to dehydration. Possible mechanisms for the dehydration is discussed on the basis of NMR spectroscopic detection of intermediary species. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.

Efficient synthesis of primary amides using 2-mercaptopyridone-1-oxide-based uronium salts

S-(1-Oxido-2-pyridinyl)-1,1,3,3-tetramethylthiouronium tetrafluoroborate (TOTT) and hexafluorophosphate (HOTT) are cheap and convenient reagents for the rapid and high-yielding preparation of primary amides when reacted with carboxylic acids and ammonium chloride in the presence of diisopropylethylamine. The reaction is chemoselective and undesired ammonolysis of other sensitive functional groups is not observed. (C) 2000 Elsevier Science Ltd.