5782-70-7

Basic information

• Product Name: 2-Pyrimidinamine, 4-(1-methylethyl)- (9CI)
• Synonyms: 2-Pyrimidinamine, 4-(1-methylethyl)- (9CI);4-isopropyl-2-pyrimidinamine(SALTDATA: FREE);(4-isopropylpyrimidin-2-yl)amine;4-isopropyl-2-pyrimidinamine;4-isopropylpyrimidin-2-amine hydrochloride;4-propan-2-ylpyrimidin-2-amine
• CAS NO: 5782-70-7
• Molecular Formula: C₇H₁₁N₃
• Molecular Weight: 137.18234
• Product Categories: PYRIMIDINE
• Mol File: 5782-70-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyrimidinamine, 4-(1-methylethyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, 4-(1-methylethyl)- (9CI)(5782-70-7)
• EPA Substance Registry System: 2-Pyrimidinamine, 4-(1-methylethyl)- (9CI)(5782-70-7)

Safety Data

• Hazardous Substances Data: 5782-70-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyrimidinamine, 4-(1-methylethyl)(9CI) is used as a building block for the synthesis of biologically active compounds, contributing to the development of new drugs and therapeutic agents.
Used in Research Applications:
In the field of research, 2-Pyrimidinamine, 4-(1-methylethyl)(9CI) is employed as a reagent in organic synthesis and chemical research, aiding in the exploration and understanding of various chemical reactions and processes.

Upstream product

• 116344-09-3 2-dimethylaminomethylene-4-methyl-3-oxo-pentanoic acid ethyl ester 
• 109-12-6 2-aminopyrimidine 
• 75-26-3 isopropyl bromide 
• 127957-84-0 2-Amino-4-isopropyl-pyrimidine-5-carboxylic acid ethyl ester 
• 127958-03-6 2-Amino-4-isopropyl-pyrimidine-5-carboxylic acid 

Relevant articles and documents

Mechanochemical Magnesium-Mediated Minisci C-H Alkylation of Pyrimidines with Alkyl Bromides and Chlorides

A novel method to synthesize 4-alkylpyrimidines by the mechanochemical magnesium-mediated Minisci reaction of pyrimidine derivatives and alkyl halides has been reported. The reaction process operates with a broad substrate scope and excellent regioselectivity under mild conditions with no requirement of transition-metal catalysts, solvents, and inert gas protection. The practicality of this protocol has been demonstrated by the up-scale synthesis, mechanochemical product derivatization, and antimalarial drug pyrimethamine preparation.

Design and synthesis of a novel series of 4-heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR

Quinuclidine-containing spirooxazolines, as described in the previous report in this series, were demonstrated to have utility as α7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists. In this work, the SAR of this chemotype was expanded to include an array of diazine heterocyclic substitutions. Many of the heterocyclic analogs were potent partial agonists of the α7 receptor, selective against other nicotinic receptors and the serotinergic 5HT3A receptor. (1′S,3′R,4′S)-N-(6-phenylpyrimidin-4-yl)-4H-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octan]-2-amine, a potent and selective α7 nAChR partial agonist, was demonstrated to improve cognition in the mouse novel object recognition (NOR) model of episodic memory.

Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.

PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

QUINUCLIDINE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic α7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.

Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. VIII. Synthesis of Ethyl and Methyl 2,4-Disubstituted 5-Pyrimidinecarboxylates

Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with N-C-N dinucleophiles such as guanidine, acetamidine or benzamidine afforded in high yields the relative esters of 4-substituted 2-amino-, 2-methyl- or 2-phenyl-5-pyrimidinecarboxylic acids, respectively.These esters were hydrolyzed to the corresponding carboxylic acids, which were converted by heating to 4-substituted 2-pyrimidinamines, 2-methyl or 2-phenylpyrimidines, respectively, generally in excellent yields.The 4-unsubstituted ethyl 2-amino-, 2-methyl- and 2-phenyl-5-pyrimidinecarboxylateswere obtained in moderate yields by reaction of the above dinucleophiles with ethyl 2,2-diformylacetate.These esters were hydrolyzed and the corresponding acids (with the exception of the 2-methyl derivative) were decarboxylated to give 2-pyrimidinamine and 2-phenylpyrimidine in satisfactory yields.