57822-06-7

Usage

Uses

Used in Pharmaceutical Industry:
5-OXOAZELAIC ACID is used as an antimicrobial agent for its ability to suppress the growth of bacteria and fungi on the skin, making it a potential candidate for treating skin infections.
Used in Cosmetic Industry:
5-OXOAZELAIC ACID is used as an acne treatment due to its capacity to reduce oil production in the skin and its potential anti-inflammatory effects, which can help alleviate acne symptoms.
Used in Polymer Production:
5-OXOAZELAIC ACID is used as a precursor in the synthesis of polymers, contributing to the development of various industrial materials.
Used in Organic Synthesis:
5-OXOAZELAIC ACID is used as a precursor for the synthesis of other organic compounds, playing a crucial role in the creation of new chemical entities for various applications.

InChI:InChI=1/C9H14O5/c10-7(3-1-5-8(11)12)4-2-6-9(13)14/h1-6H2,(H,11,12)(H,13,14)

Upstream product

• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 83144-49-4 4-oxo-heptane-1,3,7-tricarbonitrile 
• 108-55-4 glutaric anhydride, 
• 504-02-9 1,3-cylohexanedione 
• 1502-42-7 1,2,6-cyclononatriene 
• 5029-66-3 methyl 3-iodopropanoate 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 6414-69-3 ethyl 3-iodopropanoate 
• 20126-98-1 4-(1-cyclopentenyl)butanoic acid 
• 73194-08-8 2-[2-(ethoxycarbonyl)ethyl]-1,3-cyclohexanedione 

Downstream Products

• 40833-04-3 diethyl 5-oxononanedioate 
• 90535-05-0 3-(2,6-dioxo-cyclohexyl)-propionic acid 
• 123-99-9 azelaic acid 
• 110-94-1 1,5-pentanedioic acid 
• 110-15-6 succinic acid 
• 493-10-7 quinolizidine 
• 2111-81-1 dl-1-acetylaspidospermidine 
• 19751-76-9 dl-1,2-dehydroaspidospermidine 
• 2912-09-6 dl-aspidospermidine 
• 80063-77-0 3-benzoyl-4-oxo-5-(3-chloropropyl)-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole 
• 80053-46-9 3-benzoyl-4-oxo-8-(2-tetrahydropyranyl)-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole 
• 89650-71-5 [2-(6-Oxo-6,7,8,9-tetrahydro-pyrido[1,2-a]indol-10-yl)-ethyl]-carbamic acid benzyl ester 
• 80053-48-1 3-benzoyl-4-oxo-1,2,3,4,5,6,7,8-octahydroazonino<5,4-b>indole 
• 73554-50-4 6-oxo-10-(N-benzyl-2-aminoethyl)-6,7,8,9-tetrahydro-pyrido(1,2-a)indole 

Relevant academic research and scientific papers

α-Oxo-Ketenimines from Isocyanides and α-Haloketones: Synthesis and Divergent Reactivity

The palladium-catalyzed reaction of α-haloketones with isocyanides afforded α-oxo-ketenimines through β-hydride elimination of the β-oxo-imidoyl palladium intermediates. Reaction of these relatively stable α-oxo-ketenimines with nucleophiles such as hydrazines, hydrazoic acid, amines, and Grignard reagent afforded pyrazoles, tetrazole, β-keto amidines, and enaminone, respectively, with high chemoselectivity. Whereas amines attack exclusively on the ketenimine functions, the formal [3+2] cycloaddition between N-monosubstituted hydrazines and α-oxo-ketenimines was initiated by nucleophilic addition to the carbonyl group.

α-Cycloalkyl-substituted ω-keto-dicarboxylic acids as lipid regulating agents

A series of cycloalkyl-substituted oxo-alkanedicarboxylic acids have been prepared by the TosMIC methodology departing from haloalkyl-substituted cycloalkylcarboxylic esters. cyclopropyl derivatives showed IC50 activity in the 0.3-1.0 μM range

A SYNTHETHIC ROAD TO THE FOREST OF STRYCHNOS, ASPIDOSPERMA, SCHIZOZYGANE AND EBURNAMINE ALKALOIDS BY WAY OF THE NOVEL PHOTOISOMERIZATION

The novel photoisomerization of 1-acylindoles accompanied by a conversion of indole to indolenine afforded 3-acylindolenines, a so far unknown reactive species, as a major product.This reaction was thorougly investigated and applied with success to the total synthesis of Strychnos, Aspidosperma, Schizozygane and Eburnamine alkaloids through a versatile intermediate 9-membered ring system,synthesized in a one pot reaction by photolysis and the simultaneous ring enlargement.