57822-43-2

Upstream product

• 77-78-1 dimethyl sulfate 
• 711-79-5 1-hydroxy-2-acetonaphthone 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 114202-89-0 3-hydroxy-2-(3-methoxy-phenyl)-benzo[h]chromen-4-one 
• 71601-13-3 2-(3-methoxyphenyl)-4H-benzo[h]chromen-4-one 
• 1446419-60-8 3-(1-hydroxynaphthalen-2-yl)-N,5-bis(3-methoxyphenyl)-2-pyrazoline-1-carbothioamide 
• 1446419-59-5 3-(1-hydroxynaphthalen-2-yl)-5-(3-methoxyphenyl)-N-(2-methoxyphenyl)-2-pyrazoline-1-carbothioamide 
• 1446419-58-4 3-(1-hydroxynaphthalen-2-yl)-N-phenyl-5-(3-methoxyphenyl)-2-pyrazoline-1-carbothioamide 
• 1449750-25-7 2-(5-(3-methoxyphenyl)-4,5-dihydro-1H-pyrazol-3-yl)naphthalen-1-ol 
• 1446419-62-0 N-(2,4-dimethoxyphenyl)-3-(1-hydroxynaphthalen-2-yl)-5-(3-methoxyphenyl)-2-pyrazoline-1-carbothioamide 
• 1446419-61-9 3-(1-hydroxynaphthalen-2-yl)-5-(3-methoxyphenyl)-N-(4-methoxyphenyl)-2-pyrazoline-1-carbothioamide 

Relevant academic research and scientific papers

Fungal metabolism of naphthoflavones

Naphthoflavones (benzoflavones) are synthetic flavonoids commonly used in drug metabolism studies as selective activators or inhibitors of cytochrome P-450 enzymes. Nowadays they are also used as a component of food supplements for body builders. There is

Complete assignments of 1H and 13C NMR data for 21 naphthalenyl-phenyl-pyrazoline derivatives

To find potent new chemotherapy drugs, we designed and synthesized a series of naphthochalcones bearing naphthalenyl-phenyl-pyrazoline moieties. The complete 1H and 13C NMR data for these compounds are reported here and can be used t

Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein

Breast cancer resistance protein (BCRP/ABCG2) belongs to the ATP binding cassette family of transport proteins. BCRP has been found to confer multidrug resistance in cancer cells. A strategy to overcome resistance due to BCRP overexpression is the investigation of potent and specific BCRP inhibitors. The aim of the current study was to investigate different multi-substituted chalcones for their BCRP inhibition. We synthesized chalcones and benzochalcones with different substituents (viz. OH, OCH3, Cl) on ring A and B of the chalcone structure. All synthesized compounds were tested by Hoechst 33342 accumulation assay to determine inhibitory activity in MCF-7 MX and MDCK cells expressing BCRP. The compounds were also screened for their P-glycoprotein (P-gp) and Multidrug resistance-associated protein 1 (MRP1) inhibitory activity in the calcein AM accumulation assay and were found to be selective towards inhibition of BCRP. Substituents at position 2′ and 4′ on chalcone ring A were found to be essential for activity; additionally there was a great influence of substituents on ring B. Presence of 3,4-dimethoxy substitution on ring B was found to be optimal, while presence of 2- and 4-chloro substitution also showed a positive effect on BCRP inhibition.

Synthesis and complete assignment of NMR data of 20 chalcones

Chalcones, intermediates in flavonoid biosynthesis, can exhibit antibacterial, antiproliferative, and anti-inflammatory properties. Chalcones contain two benzene rings and both hydroxylated and methoxylated analogs are frequently produced by hydroxylases and O-methyltransferases in plant biosynthetic pathways. Assignments of NMR peaks in the spectra of hydroxylated and/or methoxylated chalcones can help in identifying novel chalcone derivatives isolated from natural sources by referencing these data against NMR spectra obtained from known chalcones. We report here the syntheses of 20 chalcones and complete assignments of 1H and 13C NMR spectra. Copyright