711-79-5Relevant articles and documents
Hauser,Rhee
, p. 178 (1978)
Manganese triacetate oxidation of methyl 1-hydroxy-2-naphthalene carboxylates
Munive, Laura,Gómez-Calvario, Víctor,Olivo, Horacio F.
, p. 2445 - 2447 (2017)
Manganese-triacetate mediated oxidation of 1-hydroxy-2-napthalene carboxylates in benzene under anhydrous conditions delivers the dimerized product. However, acetoxylation on the ortho- or para-position, or oxidation to quinones occurs on the 1-hydroxy-3-substituted 2-napthalene carboxylates depending on the nature of the substituents when the reaction is carried out in a mixture of acetic acid/acetonitrile.
Synthesis and supramolecular structure of 2-acetyl-1-naphthol
Su, Qiong,Zhang, Xin-Ying,Zhang, Yu-Jie,Zhao, Li,Wang, Li,Wang, Yan-Bin
, p. 5115 - 5116 (2013)
2-Acetyl-1-naphthol with the molecular formula C12H10O2, is stabilized by intramolecular O2-H2...O1 hydrogen bond forming a six-membered ring, nearly planar with the naphthone ring and the distances from C1 atom of acetyl group to mean plane of the three six-membered ring is 0.112(3) ?. Moreover, the structure is stabilized by intermolecular C-H...p and p-p stacking interactions.
Benzoflavone derivatives as potent antihyperuricemic agents
Singh, Jatinder V.,Mal, Gurbachan,Kaur, Gurleen,Gupta, Manish K.,Singh, Amritpal,Nepali, Kunal,Singh, Harbinder,Sharma, Sahil,Bedi, S. Preet Mohinder
, p. 128 - 147 (2019/01/30)
Two series of benzoflavone derivatives were rationally designed, synthesized and evaluated for their xanthine oxidase (XO) inhibitory potential. Among both series, eight compounds (NF-2, NF-4, NF-9, NF-12, NF-16, NF-25, NF-28, and NF-32) were found to exert significant XO inhibition with IC50 values lower than 10 μM. Enzyme kinetic studies revealed that the most potent benzoflavone derivatives (NF-4 and NF-28) are mixed type inhibitors of the XO enzyme. Molecular modeling studies were also performed to investigate the binding interactions of these molecules (NF-4 and NF-28) with the amino acid residues present in the active site of the enzyme. Docking results confirmed that their favorable binding conformations in the active site of XO can completely block the catalytic activity of the enzyme. Benzoflavone derivatives exhibiting potent XO enzyme inhibition also showed promising results in a hyperuricemic mice model when tested in vivo.
ATF3 INDUCTION COMPOUNDS
-
, (2018/10/19)
Provided are compounds for treating and/or preventing obesity and obesity-related disorders. Particularly, provided are chromanone derivatives used as ATF3 inducer and for treating and/or preventing obesity and obesity-related disorders such as heart disease, hypertension, hyperlipidemia and diabetes.