57841-11-9Relevant academic research and scientific papers
New chemoenzymatic pathway for β-adrenergic blocking agents
Kamal, Ahmed,Khanna, G.B. Ramesh,Krishnaji,Tekumalla, Venkatesh,Ramu
, p. 1485 - 1494 (2007/10/03)
The lipase mediated kinetic resolution of pharmaceutically important β-hydroxy nitriles is described in high enantiomeric excesses and good yields. Some of the chiral β-hydroxy nitriles have been employed in the synthesis of β-adrenergic blocking agents such as propranolol, alprenolol and moprolol. This protocol has also been extended for the enantiopure preparation of 5-(4-tosyloxymethyl)-1,3-oxazolidine-2-one and 3-hydroxy-4-tosyloxybutanenitrile, chiral intermediates of high synthetic value.
Regiospecific opening of 1,2-epoxides with acetone cyanohydrin under mildly basic conditions
Mitchell,Koenig
, p. 3281 - 3284 (2007/10/02)
Acetone cyanohydrin with stoichiometric triethylamine opens epoxides regiospecifically to give β-hydroxy nitriles. As expected, addition of cyanide occurs at the least substituted carbon.
