57845-06-4Relevant academic research and scientific papers
Microwave-irradiated synthesis and biological evaluation of 3,5-diaryl-1-phenyl-2-pyrazolines as antibacterial and anti-inflammatory agents
Kumar, Anjan,Rout, Sradhasini,Panda, Jnyanaranjan,Sahoo, Biswa Mohan,Banik, Bimal Krishna
, p. 1321 - 1326 (2020/06/27)
In a wide search program towards a biologically active antibacterial and anti-inflammatory agents, a series of 3,5-diaryl-1-phenyl-2-pyrazoline have been synthesized with excellent yields employing microwave techniques starting from substituted α,β-unsaturated carbonyl compounds which undergo cyclization reactions with phenylhydrazine. The structures of newly synthesized compounds were characterized and confirmed on the basis of FT-IR, 1H NMR and mass spectral analyses. The synthesized compounds 3,5-diaryl-1-phenyl-2-pyrazolines had shown significant activity against Staphylococcus aureus (MTCC 87), Escherichia coli (MTCC 40), Pseudomonas aeruginosa (MTCC 424) and Proteus vulgaris (MTCC 426) by cup plate method using tetracycline-SD 037 as a reference standard. The anti-inflammatory property of 1,3,5-diaryl-1-phenyl-2-pyrazolines were screened by using carragenan induced paw edema method in Wistar rat. The anti-inflammatory activities were comparable to that of the standard drug diclofenac. The safety of 3,5-diaryl-1-phenyl-2-pyrazolines were reflected by toxicity studies.
Antimicrobial, analgesic, DPPH scavenging activities and molecular docking study of some 1,3,5-triaryl-2-pyrazolines
Samshuddin, Seranthimata,Narayana, Badiadka,Sarojini, Balladka Kunhanna,Raj, Chenna Govindaraju Darshan,Khan, Mahmud Tareq Hassan,Yathirajan, Hemmige S.,Raghavendra, Ramappa
, p. 2012 - 2022,11 (2020/07/30)
A series of 1,3,5-triaryl-2-pyrazolines 2a-g were synthesized by the reaction of 4,40-disubstituted chalcone with phenyl hydrazine. All these compounds were characterized by NMR, IR and mass spectral and single crystal XRD data. All the synthesized produc
Novel chalcones and 1,3,5-triphenyl-2-pyrazoline derivatives as antibacterial agents
Sivakumar, Ponnurengam Malliappan,Ganesan, Suresh,Veluchamy, Prabhawathi,Doble, Mukesh
, p. 407 - 411 (2012/07/17)
Novel sixteen chalcones and thirteen 1,3,5-triphenyl-2-pyrazolines were synthesized and characterized using FT-IR, HR-Mass, NMR (1H-NMR, 13C-NMR, 135 DEPT, 1H-1H CoSY and 1H and 13C CoSY) a
Improved synthesis of chalcones and pyrazolines under ultrasonic irradiation
Gupta, Ragini,Gupta, Neetu,Jain, Anshu
experimental part, p. 351 - 355 (2010/11/03)
Five 1,3-diarylprop-2-en-1-ones 3a-e are synthesized by Claisen-Schmidt condensation of aryl methyl ketones and 4chlorobenzaldehyde to give pyrazolines 5a-e by cyclization with Phenylhydrazine in gl. acetic acid using ultrasonic irradiation in lesser time
Mechanically activated synthesis of 1,3,5-triaryl-2-pyrazolines by high speed ball milling
Zhu, Xingyi,Li, Zhenhua,Jin, Can,Xu, Li,Wu, Qianqian,Su, Weike
experimental part, p. 163 - 165 (2010/04/22)
An efficient mechanically activated solvent-free synthesis of 1,3,5-triaryl-2-pyrazolines from chalcones and phenylhydrazines using high speed ball milling is described. This method has notable advantages in terms of good yield, short reaction time and ne
A modified and convenient method for the preparation of N-phenylpyrazoline derivatives
Safaei-Ghomi,Bamoniri,Soltanian-Telkabadi
, p. 892 - 896 (2008/02/10)
Ten new N-phenylpyrazoline derivatives have been synthesized in high yields by condensation of chalcones with phenylhydrazine in the presence of potassium carbonate in reflux conditions. The workup is simple and involves treatment with ice-cold water. As compared with the previous method a considerable increase in the reaction rate with better yields has been observed.
