57856-66-3Relevant academic research and scientific papers
Development of a novel class of pyrrolo-[1,2,5]benzothiadiazepine derivatives as potential anti-schistosomal agents
Chen, Jinglei,Sun, Weizhen,Yang, Jingjing,Sun, Huan,Wang, Zhixia,Dong, Lanlan,Qiao, Chunhua,Xia, Chao-Ming
, p. 3785 - 3787 (2013)
Analogues of pyrrolo-[1,2,5]benzothiadiazepine were prepared and evaluated against Schistosoma japonica. The biological data revealed that most benzothiazepine derivatives show anti-schistosomal activity to some extent, while α-chloronation of the title compound and another bioisosteric derivative pyrrolo-[1,2,5]benzodiazepine displayed the most distinct worm killing activity. This study proved that benzodiazepine may serve as a novel structural skeleton for the development of anti-schistosomal agents.
