57872-32-9

Upstream product

• 920-39-8 isopropylmagnesium bromide 
• 534-07-6 1,3-Dichloroacetone 
• 74-96-4 ethyl bromide 
• 547-63-7 Methyl isobutyrate 
• 539-74-2 Ethyl 3-bromopropionate 
• 925-90-6 ethylmagnesium bromide 
• 1026206-49-4 2-chloromethyl-2-isopropyloxirane 
• 180331-43-5 1-chloro-2-(chloromethyl)-3-methyl-2-butanol 

Downstream Products

• 25044-03-5 4-methyl-3-oxopentanal 

Relevant academic research and scientific papers

Ni-Catalyzed Denitrogenative Cross-Coupling of Benzotriazinones and Cyclopropanols: An Easy Access to Functionalized β-Aryl Ketones

A novel Ni-catalyzed denitrogenative cross-coupling between benzotriazinones and cyclopropanols is reported herein. This neoteric reactivity allows for the convenient synthesis of β-(o-amido)aryl ketones from readily available starting materials with good yields (up to 93percent) and general substrate scope.

Biologically active compounds

The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of a disease selected from osteoporosis, Paget's disease, Chagas's disease, malaria, gingival diseases, hypercalaemia, metabolic bone disease and diseases involving matrix or cartilate degradation.

NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Reactions of 2-substituted epichlorohydrins

2-Substituted epichlorohydrins have been synthesized by starting with 1,2-dichloro acetone and various alkyl and aryl halides via dichlorohydrins followed by cyclization. The reactive 2-substituted epichlorohydrins were subjected to nucleophilic attacking of azide and cyanide ions to afford corresponding β-azido alcohols and α,β-unsaturated nitriles.

Alkylation-annulation of halo esters with organometallic reagent/SmI2 couple leading to cycloalkanols: A facile cyclopropanol synthesis from a 3-halo ester

Transformation of a 3-halo ester to cyclopropanols has been accomplished in excellent yields under mild conditions employing a coupled reagent of samarium(II) diiodide with organometallic reagents. 5- and 6-Halo esters were also transformed into cyclopentanols and cyclohexanols, respectively, in low to moderate yields. The reaction with a 4-halo ester gave 2,2-disubstituted tetrahydrofuran as a major product that resulted from double alkylation followed by cyclization; a substituted cyclobutanol was formed in poor yield.

REACTION OF ALKYLMAGNESIUM HALIDES WITH CARBOXYLIC ESTERS IN THE PRESENCE OF TETRAISOPROPOXYTITANIUM

The reaction of carboxylic esters with a threefold molar excess of ethylmagnesium bromide in the presence of an equimolar amount of tetraisopropoxytitanium leads to the formation of the corresponding 1-substituted 1-cyclopropanols.Propyl-, butyl-,and 2-phenylethylmagnesium bromides enter into a similar reaction, leading to 1,2-disubstituted 1-cyclopropanols.

TETRAISOPROPOXYTITANIUM-CATALYZED REACTION OF ALKYLMAGNESIUM HALIDES WITH ESTERS AS A CONVENIENT METHOD FOR THE PRODUCTION OF SUBSTITUTED CYCLOPROPANOLS

The reaction of alkylmagnesium halides with carboxylic esters at room temperature in the presence of tetraisopropoxytitanium gives good yields of the respective 1-substituted cyclopropanols.

A facile cyclopropanol synthesis from β-halo ester with Grignard reagent-samarium(II) diiodide couple

Transformation of α,β-halo ester to the cyclopropanols by a coupled reagent of samarium(II) diiodide with Grignard reagent in tetrahydrofuran-hexamethylphosphoric triamide was very successful under mild conditions.