578740-35-9Relevant academic research and scientific papers
Chiral dirhodium(II) catalysts with ortho-metalated arylphosphine ligands: Synthesis and application to the enantioselective cyclopropanation of α-diazo ketones
Barberis, Mario,Pérez-Prieto, Julia,Herbst, Konrad,Lahuerta, Pascual
, p. 1667 - 1673 (2002)
Chiral dirhodium(II) compounds, Rh2(O2CR)2(pc)2 (pc = ortho-metalated arylphosphine), with a head-to-tail arrangement (1-21) are used in the cyclopropanation of α-diazo ketones. The influence of catalyst ligands and substrate structure on enantioselectivity is studied. Temperature and solvent dependence assays are performed, the best ee values being obtained in refluxing pentane. Results compare favorably with those reported in the literature using Ru, Cu, and other Rh(II) catalysts.
