57882-27-6Relevant academic research and scientific papers
A simple preparation of a functionalized diimine ligand: 2-(2-pyridyl)- 4-carboxyquinoline
Bass, Yakov,Morgan, Robert J.,Donovan, Robert J.,Baker
, p. 2165 - 2169 (1997)
A convenient single step preparation of the carboxylate functionalized diimine ligand, 2-(2-pyridyl)-4-carboxyquinoline 1 from isatin 2 and 2- acetylpyridine 3 is reported.
Energy efficient Pfitzinger reaction: A novel strategy using a surfactant catalyst
More, Priyanka A.,Shankarling, Ganapati S.
supporting information, p. 12380 - 12383 (2017/11/06)
A novel energy efficient method for the Pfitzinger reaction is demonstrated, which is catalysed using a surfactant, cetyltrimethylammonium hydroxide. The surfactant nature of the catalyst caused the substrate to be soluble in aqueous media, which enhanced the interaction of the catalyst with the substrate. An increase in the rate of reaction and more than 78% of energy saving were observed under ultrasonic irradiation.
Synthesis, characterization, electrochemical and theoretical study of substituted phenyl-terpyridine and pyridine-quinoline based mixed chelate ruthenium complexes
Mongal, Binitendra Naath,Naskar, Subhendu
, p. 451 - 462 (2017/01/28)
In the present work, we report two methoxy-substituted phenyl-terpyridine ruthenium complexes with pyridine carboxyquinoline and NCS as ancillary ligands, [Ru(OMePhtpy)(pcqH)(NCS)](PF6) (1) and [Ru(triOMePhtpy)(pcqH)(NCS)](PF6) (2) (
Synthesis, characterisation, electrochemical study and photovoltaic measurements of a new terpyridine and pyridine-quinoline based mixed chelate ruthenium dye
Mongal, Binitendra Naath,Pal, Arunava,Mandal, Tarun Kanti,Datta, Jayati,Naskar, Subhendu
, p. 615 - 626 (2015/12/05)
A novel ruthenium-terpyridine based photosensitizer, Ru[(p-F-tpy)(pcqH)Cl] PF6 (1); (p-F-tpy = 4′-(4-fluorophenyl)-2,2′:6′,2″-terpyridine, pcqH = 2-(2-pyridyl)-4-carboxyquinoline) was synthesized and spectroscopically characterized. The electro
Comparative study of the affinity and metabolism of type i and type II binding quinoline carboxamide analogues by cytochrome P450 3A4
Dahal, Upendra P.,Joswig-Jones, Carolyn,Jones, Jeffrey P.
supporting information; experimental part, p. 280 - 290 (2012/03/10)
Compounds that coordinate to the heme-iron of cytochrome P450 (CYP) enzymes are assumed to increase metabolic stability. However, recently we observed that the type II binding quinoline carboxamide (QCA) compounds were metabolically less stable. To test if the higher intrinsic clearance of type II binding compounds relative to type I binding compounds is general for other metabolic transformations, we synthesized a library of QCA compounds that could undergo N-dealkylation, O-dealkylation, benzylic hydroxylation, and aromatic hydroxylation. The results demonstrated that type II binding QCA analogues were metabolically less stable (2- to 12-fold) at subsaturating concentration compared to type I binding counterparts for all the transformations. When the rates of different metabolic transformations between type I and type II binding compounds were compared, they were found to be in the order of N-demethylation > benzylic hydroxylation> O-demethylation > aromatic hydroxylation. Finally, for the QCA analogues with aza-heteroaromatic rings, we did not detect metabolism in aza-aromatic rings (pyridine, pyrazine, pyrimidine), indicating that electronegativity of the nitrogen can change regioselectivity in CYP metabolism.
Macromolecular ligands carrying side bipyridyl-containing groups and their metal-polymer complexes with iridium
Goikhman, M. Ya.,Polevoi,Podeshvo,Loretsyan,Gofman,Smyslov, R. Yu.,Popova,Pokhvoshchev, Yu. V.,Krasikov,Yakimanskii
, p. 1703 - 1710 (2013/04/10)
A series of copolyamides carrying side bipyridyl-containing groups and their metal-polymer complexes with iridium were synthesized. The stress-strain, thermal, molecular-weight, and luminescent characteristics of these compounds were examined. All the pol
Synthesis and properties of iridium polymer complexes based on novel bipyridyl ligands
Goikhman, M. Ya.,Podeshvo,Loretsyan,Gofman,Smyslov, R. Yu.,Nekrasova,Smirnova,Polevoi,Yakimanskii
, p. 966 - 972 (2013/07/25)
A novel monomer, viz., bipyridyl-containing dicarboxylic acid, was synthesized from 6-pyridyl-3,4-pyridine dicarboxylic acid anhydride and 5-aminoisophthalic acid. Novel polymer macroligands, viz., copolyamides containing 5, 15, 30, and 45% of the bipyrid
Small molecule quantification by liquid chromatography-mass spectrometry for metabolites of drugs and drug candidates
Dahal, Upendra P.,Jones, Jeffrey P.,Davis, John A.,Rock, Dan A.
experimental part, p. 2355 - 2360 (2012/03/26)
Identification and quantification of the metabolites of drugs and drug candidates are routinely performed using liquid chromatography-mass spectrometry (LC-MS). The best practice is to generate a standard curve with the metabolite versus the internal standard. However, to avoid the difficulties in metabolite synthesis, standard curves are sometimes prepared using the substrate, assuming that the signal for substrate and the metabolite will be equivalent. We have tested the errors associated with this assumption using a series of very similar compounds that undergo common metabolic reactions using both conventional flow electrospray ionization LC-MS and low-flow captive spray ionization (CSI) LC-MS. The differences in standard curves for four different types of transformations (O-demethylation, N-demethylation, aromatic hydroxylation, and benzylic hydroxylation) are presented. The results demonstrate that the signals of the substrates compared with those of the metabolites are statistically different in 18 of the 20 substrate-metabolite combinations for both methods. The ratio of the slopes of the standard curves varied up to 4-fold but was slightly less for the CSI method. Copyright
Cytochrome P450 2C9 type II binding studies on quinoline-4-carboxamide analogues
Peng, Chi-Chi,Cape, Jonathan L.,Rushmore, Tom,Crouch, Gregory J.,Jones, Jeffrey P.
experimental part, p. 8000 - 8011 (2009/12/07)
CYP2C9 is a significant P450 protein responsible for drug metabolism. With the increased use of heterocyclic compounds in drug design, a rapid and efficient predrug screening of these potential type II binding compounds is essential to avoid adverse drug
Imidazolium cations, processes for their preparation, and uses therefor
-
, (2008/06/13)
Novel imidazolium compounds of the formula STR1 wherein A represents the atomic group necessary to form a heteroaromatic ring, which may be optionally substituted by one or more R substituents selected from the group consisting of aryl, heteroaryl, lower alkyl, hydroxy, halide, or carboxy substitutents; B is an optional substituent which represents the atomic group necessary to form a heteroaromatic ring or a double or triple carbon-nitrogen bond, which may optionally be substituted by one or more R' substituents selected from the group consisting of aryl, heteroaryl, lower alkyl, hydroxy, halide, or carboxy substitutents; C is an optional substituent which represents the atomic group necessary to form an aromatic or heteroaromatic ring, which may optionally be substituted by one or more R"" substituents selected from the group consisting of aryl, heteroaryl, lower alkyl, hydroxy, halide, or carboxy substituents; R" and R'" are each independently a lower alkyl or aryl group, or together with the nitrogen atom to which they are attached, form a heterocyclic ring having from 5 to 7 members, which may optionally contain a sulfur, oxygen, silicon, selenium or an additional nitrogen atom; and X is an anion; are useful in a variety of industrial and medical applications.
