5790-86-3Relevant academic research and scientific papers
A novel class of allosteric modulators of AMPA/Kainate receptors
Cannazza, Giuseppe,Jozwiak, Krzysztof,Parenti, Carlo,Braghiroli, Daniela,Carrozzo, Marina M.,Puia, Giulia,Losi, Gabriele,Baraldi, Mario,Lindner, Wolfgang,Wainer, Irving W.
, p. 1254 - 1257 (2009)
The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.
