57934-06-2

Upstream product

• 107971-47-1 (2R,6R)-2-(4-Hydroxy-butyl)-4-oxo-6-phenyl-piperidine-1-carboxylic acid benzyl ester 
• 107971-45-9 4-Oxo-2-(4-trimethylsilanyloxy-butyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester 
• 107971-44-8 N-<(benzyloxy)carbonyl>-2-(4-hydroxybutyl)-2,3-dihydro-4-pyridone 
• 1122-96-9 4-methoxypyridine N-oxide 
• 620-08-6 4-methoxypyridine 
• 505-18-0 2,3,4,5-tetrahydropyridine 
• 100-52-7 benzaldehyde 
• 4396-01-4 isopelletierine 
• 107971-49-3 (2R,6R)-4-Oxo-2-phenyl-6-[4-(toluene-4-sulfonyloxy)-butyl]-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis and Stereochemistry of Some New Diazatricyclic Compounds

The diazatricyclic ketone 3 was synthesized by a double Mannich condensation starting from 2-quinolizidone (2).Reductions of 3 by complex hydrides and hydrazine gave a mixture of isomeric amino alcohols rac-4/5 and the diamine 6, respectively.Compounds rac-4 and rac-5 could be separated by selective acylation with 4-chlorobenzoyl chloride due to the fundamental steric differences in the N --> O acyl transfer interactions within the isomeric molecules.The cis- and trans-4-phenyl-2-quinolizidones (rac-10, rac-11) also underwent a Mannich condensation affording the same product rac-12 in both cases. - Key Words: 7,11-Diazatricyclo2,7>tridecanes / Cytisine analogues

ADDITION OF GRIGNARD REAGENTS TO 1-ACYL-4-METHOXYPYRIDINIUM SALTS. AN APPROACH TO THE SYNTHESIS OF QUINOLIZIDINONES.

The addition of Grignard reagents to 1-acyl-4-methoxypyridinium salts gives 2-substituted 1-acyl-2,3-dihydropyridones.This reaction was utilized to synthesize (+/-)-epi-myrtine and trans-4-phenylquinolizidin-2-one.