57939-39-6Relevant articles and documents
CHEMICAL COMPOUNDS - 795
-
Page/Page column 28, (2009/04/25)
The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula (I): which have bacterial Murl inhibitory activity and are accordingly useful for their treatment and prophylaxis of bacterial infection, e.g., E.faec
Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria
Breault, Gloria A.,Comita-Prevoir, Janelle,Eyermann, Charles J.,Geng, Bolin,Petrichko, Randy,Doig, Peter,Gorseth, Elise,Noonan, Brian
scheme or table, p. 6100 - 6103 (2009/07/18)
A successful scaffold-hopping approach gave a novel series of inhibitors of bacterial glutamate racemase (MurI). Early SAR studies of the 8-benzyl pteridine-6,7-diones led to compounds with micromolar enzyme potency and antibacterial activity.
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2
Sayle, Kerry L.,Bentley, Johanne,Boyle, F. Thomas,Calvert, A. Hilary,Cheng, Yuzhu,Curtin, Nicola J.,Endicott, Jane A.,Golding, Bernard T.,Hardcastle, Ian R.,Jewsbury, Philip,Mesguiche, Veronique,Newell, David R.,Noble, Martin E. M.,Parsons, Rachel J.,Pratt, David J.,Wang, Lan Z.,Griffin, Roger J.
, p. 3079 - 3082 (2007/10/03)
A series of O4-cyclohexylmethyl-5-nitroso-6-aminopyrimidines bearing 2-arylamino substituents was synthesised and evaluated for CDK1 and CDK2 inhibitory activity. Consistent with analogous studies with O 6-cyclohexylmethylpurines, 2-
