57939-40-9Relevant academic research and scientific papers
Halocyclization of 2-allyl(propargyl)sulfanyl-6-aminopyrimidin-4(3H)-ones
Kim,Osheko, K. Yu.,Frolova
, p. 1899 - 1902 (2017)
The alkylation of 6-amino-2-thiouracil with allyl, methallyl, and propargyl halides in the presence of bases gave 2-[allyl(methallyl, propargyl)sulfanyl]-6-aminopyrimidin-4(3H)-ones which reacted with iodine and bromine to form fused [1,3]thiazolo[3,2-a]pyrimidinium systems. Their nitrosation with sodium nitrite in acid medium afforded 2-[allyl(propargyl)sulfanyl]-6-amino-5-nitrosopyrimidin-4(3H)-ones.
Halocyclization of substituted 2-(alkenylthio)pyrimidin-6-ones
Slivka,Gevaza,Staninets
, p. 660 - 666 (2004)
Bromination and iodation of 2-(alkenylthio)pyrimidin-6-ones occur selectively and lead to formation of the corresponding 7-oxo-2,3- dihydrothiazolopyrimidinium or 8-oxo-3,4-dihydro-2H-pyrimidothiazinium salts. The selectivity of the reaction is controlled
Pyrimidinone derivative, preparation method thereof and application thereof in resisting mycobacterium tuberculosis infection
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Paragraph 0163-0168, (2020/11/25)
The invention discloses a pyrimidinone derivative, a preparation method thereof and an application thereof in resisting mycobacterium tuberculosis infection. The structure of the pyrimidinone derivative is shown as a formula I, wherein R1, m, X, Y, Z, R2
