579461-41-9Relevant academic research and scientific papers
Radioactive iodine marked Larotrectinib compound, and preparation method and application thereof
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Paragraph 0303; 0307-0310, (2019/04/26)
The invention relates to a radioactive iodine marked Larotrectinib compound, and a preparation method and application thereof. The provided compounds comprise the radioactive iodine marked Larotrectinib compound with the following structural formula and a
Photoinduced cleavage of DNA by bromofluoroacetophenone-pyrrolecarboxamide conjugates
Wender, Paul A.,Jeon, Raok
, p. 1763 - 1766 (2007/10/03)
Bromofluoroacetophenone derivatives which produce fluorine substituted phenyl radicals that cleave DNA upon excitation were investigated as a novel photonuclease. Pyrrolecarboxamide-conjugated bromofluoroacetophenones; 4′-bromo-2′-fluoroacetophenone and 2′-bromo-4′-fluoroacetophenone were synthesized and their DNA cleaving activities and sequence selectivities were determined. Bromofluoroacetophenone-pyrrolecarboxamide conjugates were found to be effective DNA cleaving agents upon irradiation in concentration dependent manner based on plasma relaxation assay. The DNA cleaving activities of 2′-bromo-4′-fluoroacetophenone derivatives were larger than those of 4′-bromo-2′-fluoroacetophenone derivatives.
