579461-39-5Relevant academic research and scientific papers
Photoinduced cleavage of DNA by bromofluoroacetophenone-pyrrolecarboxamide conjugates
Wender, Paul A.,Jeon, Raok
, p. 1763 - 1766 (2003)
Bromofluoroacetophenone derivatives which produce fluorine substituted phenyl radicals that cleave DNA upon excitation were investigated as a novel photonuclease. Pyrrolecarboxamide-conjugated bromofluoroacetophenones; 4′-bromo-2′-fluoroacetophenone and 2′-bromo-4′-fluoroacetophenone were synthesized and their DNA cleaving activities and sequence selectivities were determined. Bromofluoroacetophenone-pyrrolecarboxamide conjugates were found to be effective DNA cleaving agents upon irradiation in concentration dependent manner based on plasma relaxation assay. The DNA cleaving activities of 2′-bromo-4′-fluoroacetophenone derivatives were larger than those of 4′-bromo-2′-fluoroacetophenone derivatives.
