57948-15-9

Upstream product

• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 

Downstream Products

• 229322-23-0 6-(hydroxymethyl)benzo<1,2-c>1,2,5-oxadiazole N₁-oxide 
• 175609-23-1 5-hydroxymethylbenzofuroxan 
• 57948-14-8 2,3-Dimethylchinoxalin-6-carboxaldehyd 1,4-Dioxid 
• 1206189-04-9 (Z)-6-[2-((4-chlorophenyl)thio)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 1206189-03-8 (E)-6-[2-((4-chlorophenyl)thio)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 1206189-06-1 (Z)-6-[2-((4-methylphenyl)thio)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 1206189-05-0 (E)-6-[2-((4-methylphenyl)thio)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 1206188-98-8 (E)-6-[-2-((4-nitrophenyl)carbonyl)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 1206189-02-7 (Z)-6-[2-((4-fluorophenyl)thio)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 1206189-01-6 (E)-6-[2-((4-fluorophenyl)thio)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 1206188-95-5 (E)-6-[-2-(phenylcarbonyl)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 1206188-96-6 (E)-6-[-2-((4-chlorophenyl)carbonyl)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 
• 1206188-97-7 (E)-6-[-2-((4-methoxyphenyl)carbonyl)vinyl]benzo[c]1,2,5-oxadiazol-1-oxide 

Relevant academic research and scientific papers

One-pot methodology for conversion of o-halogen nitrobenzenes to benzofuroxans

Reaction of o-halonitrobenzenes with sodium azide under reflux of DMF/H2O gives benzofuroxans in one step in moderate to good yields. This is a faster methodology compared to the conventional procedure involving the preparation and subsequent pyrolysis of o-nitrophenyl azides. For comparison, the reaction was also performed under phase-transfer catalysis.

Piperidine compound and preparation method and medical application thereof

The invention discloses a piperidine compound shown as a formula (I) and a preparation method and medical application thereof, and particularly relates to a piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof and a preparation method and application of the piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof. The compound provided by the invention can inhibit the activity of USP7 enzyme, has very good selectivity and druggability, and can be used for preparing medicines for preventing or treating tumor diseases or virus infectious diseases.

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.