59660-56-9

Basic information

• Product Name: 2,1,3-BENZOXADIAZOL-5-YLMETHANOL
• Synonyms: 2,1,3-BENZOXADIAZOL-5-YLMETHANOL;1,2,3-BENZOXADIAZOL-5-YLMETHANOL;BUTTPARK 154\50-14;RARECHEM AL BD 1194;benzo[c][1,2,5]oxadiazol-5-ylmethanol
• CAS NO: 59660-56-9
• Molecular Formula: C₇H₆N₂O₂
• Molecular Weight: 150.13
• Mol File: 59660-56-9.mol
• Article Data: 7

Chemical Properties

• Melting Point: 66 °C
• Boiling Point: 300.1 °C at 760 mmHg
• Flash Point: 135.3 °C
• Appearance: /
• Density: 1.408 g/cm³
• Vapor Pressure: 0.00051mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 2,1,3-BENZOXADIAZOL-5-YLMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,1,3-BENZOXADIAZOL-5-YLMETHANOL(59660-56-9)
• EPA Substance Registry System: 2,1,3-BENZOXADIAZOL-5-YLMETHANOL(59660-56-9)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 59660-56-9(Hazardous Substances Data)

Usage

General Description

2,1,3-Benzoxadiazol-5-ylmethanol is a chemical compound with the molecular formula C8H7NO2. It is a fluorescent derivative of benzoxadiazole and is used as a building block in the synthesis of various fluorescent dyes and sensors. It is also utilized as a fluorescent probe for the detection of DNA and protein interactions. The compound is known for its high quantum yield and photostability, making it a useful tool in fluorescence microscopy and other biomedical applications. Additionally, it is a versatile molecule that can be functionalized for various applications in the fields of analytical chemistry, materials science, and biochemistry.

InChI:InChI=1/C7H6N2O2/c10-4-5-1-2-6-7(3-5)9-11-8-6/h1-3,10H,4H2

Upstream product

• 57948-15-9 5-formylbenzo[1,2-c]1,2,5-oxadiazole N¹-oxide 
• 42564-51-2 4-fluoro-3-nitrobenzaldehyde 
• 459-57-4 4-fluorobenzaldehyde 
• 32863-33-5 5-formylbenzofurazan 
• 19155-93-2 4-azido-3-nitrobenzaldehyde 
• 16588-34-4 4-chloro-3-nitro-benzaldehyde 
• 19164-42-2 5-formylbenzo[c][1,2,5]oxadiazole 1-oxide 
• 104-88-1 4-chlorobenzaldehyde 
• 229322-23-0 6-(hydroxymethyl)benzo<1,2-c>1,2,5-oxadiazole N₁-oxide 
• 32863-31-3 5-(bromomethyl)benzofurazan 

Downstream Products

• 32863-31-3 5-(bromomethyl)benzofurazan 
• 32863-33-5 5-formylbenzofurazan 

Relevant articles and documents

Piperidine compound and preparation method and medical application thereof

The invention discloses a piperidine compound shown as a formula (I) and a preparation method and medical application thereof, and particularly relates to a piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof and a preparation method and application of the piperidine USP7 inhibitor compound or pharmaceutically acceptable salt or ester or solvate thereof. The compound provided by the invention can inhibit the activity of USP7 enzyme, has very good selectivity and druggability, and can be used for preparing medicines for preventing or treating tumor diseases or virus infectious diseases.

Discovery of phenoxybutanoic acid derivatives as potent endothelin antagonists with antihypertensive activity

A series of phenoxybutanoic acid derivatives were synthesized and tested for their antagonistic activity on the contraction of the rat thoracic aortic ring induced by endothelin-1. Preliminary screening results showed that 6e and 6g with benzoheterocycles demonstrated significant antagonistic activities when compared to the reference compound BQ123. The results from additional assays for the binding affinity and selectivity for endothelin receptors showed that 6e was a selective ETA antagonist with a nanomolar IC50. Moreover, 6e was effective in relieving hypoxia-induced pulmonary arterial hypertension and right ventricular weight ratio. Therefore, 6e may have potential for further development as a therapeutic agent for the treatment of cardiovascular diseases.

PYROLLIDINE-BASED COMPOUNDS

A compound of formula (I) or a pharmaceutically acceptable derivative, salt or prodrug thereof, which can inhibit HIV replication.