57950-79-5Relevant academic research and scientific papers
Based on N - (2 - hydroxypropyl) methacrylamide polymer nanometer grain and its preparation method
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Paragraph 0064; 0065, (2019/02/26)
The invention discloses an N-(2-hydroxypropyl) methacrylamide polymer based nanoparticles capable of overcoming a mucus barrier and a preparation method thereof. The nanoparticles consist of nucleuses and shells, wherein the kernels are a nanometer compound prepared from a biocompatible carrier material and active ingredients, and the shells are an HPMA polymer and its derivatives.
Synthesis and characterization of a new polymer-drug conjugate with pH-induced activity
Chang, Hui-Ping,Chen, Jian-Ying,Zhong, Pei-Shan,Chang, Yung-Hsien,Liang, Mong
experimental part, p. 3498 - 3507 (2012/09/08)
A well-defined, stimuli-responsive tetrapolymer with pH-responsive characteristics and targeting specificity has been synthesized by radical copolymerization of methacrylic acid, N-(2-hydroxypropyl)methacrylamide, methacryloyl glycylglycyl sulfamethoxazol
ENZYMATICALLY CATALYZED GENERATION OF ELECTRONICALLY EXCITED STATES IN A SYNTHETIC COPOLYMER WITH A SCHIFF BASE IN PENDANT GROUPS
Zoulik, Robert,Pavlicek, Zdenek,Vohlidal, Jiri,Subr, Vladimir
, p. 95 - 103 (2007/10/02)
The copolymer of N-(2-hydroxypropyl)methacrylamide and N-hexane-1,6-diamime (17.6 mole percent) was prepared as a model compound for investigation of a mechanism of enzymatically catalyzed generation of electronically excited states in proteins.The amino end groups of the copolymer side chains were transformed into a Schiff base by reaction with glycolaldehyde.The modified copolymer was characterized by its ultraviolet, visible and fluorescence spectra.The enzymatically catalyzed oxidation of the modified copolymer was carried out in a phosphate buffer at pH 7 using horseradish peroxidase as the enzyme.The generation of electronically excited states was demonstrated by chemiluminiscence measurement and by spectroscopic procedure based on transfer of the excitation energy to bilirubin.
