579504-79-3Relevant articles and documents
Acid-catalyzed cyclization of anthracenol derivatives to homotriptycenes
Gao, Chunmei,Cao, Derong,Xu, Sheyang,Meier, Herbert
, p. 3071 - 3076 (2007/10/03)
10-Benzyl-9,10-dihydroanthracen-9-ols, having high electron densities in the benzene ring, exhibit in the presence of acid a transannular ring closure to the corresponding homotriptycenes in almost quantitative yields. Since the starting compounds are easily accessible from 9(10H)-anthracenone, this process represents the most facile route to such pentacyclic systems. An electron-releasing methoxy group enables the intramolecular electrophilic substitution in its para position. In the absence of such an activation, a number of alternative processes can occur, namely the acid-catalyzed dehydration to anthracene derivatives with (R ≠ H) or without (R = H) rearrangement or a disproportionation reaction of the secondary alcohol to the corresponding ketone and hydrocarbon.
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization
Prinz, Helge,Ishii, Yukihito,Hirano, Takeo,Stoiber, Thomas,Camacho Gomez, Juan A.,Schmidt, Peter,Düssmann, Heiko,Burger, Angelika M.,Prehn, Jochen H. M.,Günther, Eckhard G.,Unger, Eberhard,Umezawa, Kazuo
, p. 3382 - 3394 (2007/10/03)
A novel series of 10-benzylidene-9(10H)-anthracenones and 10-(phenylmethyl)-9(10H)-anthracenones were synthesized and evaluated for antiproliferative activity in an assay based on K562 leukemia cells. The 3-hydroxy-4-methoxybenzylidene analogue 9h was fou
