579508-15-9Relevant academic research and scientific papers
Non-peptide αvβ3 antagonists. Part 6: Design and synthesis of αvβ3 antagonists containing a pyridone or pyrazinone central scaffold
Breslin, Michael J.,Duggan, Mark E.,Halczenko, Wasyl,Fernandez-Metzler, Carmen,Hunt, Cecilia A.,Leu, Chih-Tai,Merkle, Kara M.,Naylor-Olsen, Adel M.,Prueksaritanont, Thomayant,Stump, Gary,Wallace, Audrey,Rodan, Sevgi B.,Hutchinson, John H.
, p. 1809 - 1812 (2007/10/03)
Two novel series of small-molecule RGD mimetics containing either a substituted pyridone or pyrazinone central constraint were prepared. Modification of the β-alanine 3-substituent produced compounds that are potent and selective αvβ3 antagonists and exhibit a range of physicochemical properties.
