57955-00-7

Upstream product

• 105-07-7 4-cyanobenzaldehyde 
• 98-98-6 2-Picolinic acid 
• 1426318-72-0 (R,S)-4-(hydroxy(pyridin-2-yl)methyl)benzonitrile 
• 57954-98-0 2-[(4-cyanophenyl)(hydrazono)methyl]pyridine 
• 57954-94-6 4-(pyridin-2-ylcarbonyl)benzonitrile 

Relevant academic research and scientific papers

Facile one-pot synthesis of [1,2,3]triazolo[1,5-a]pyridines from 2-acylpyridines by copper(II)-catalyzed oxidative N-N bond formation

An efficient and simple method for the synthesis of various [1,2,3]triazolo[1,5-a]pyridines has been established. The method involves a copper(II)-catalyzed oxidative N-N bond formation that uses atmospheric oxygen as the terminal oxidant following hydrazonation in one pot. The use of ethyl acetate as the solvent dramatically promotes the oxidative N-N bond-formation reaction and enables the application of oxidative cyclization in the efficient one-pot reaction. A mechanism for the reaction was proposed on the basis of the results of a spectroscopic study. In the same pot: [1,2,3]Triazolo[1,5-a] pyridines are synthesized from the corresponding 2-acylpyridines by a one-pot method, consisting of hydrazonation followed by oxidative cyclization through copper(II)-catalyzed N-N bond formation (see scheme).