57987-84-5Relevant articles and documents
Model studies for the total synthesis of 11-demethoxymyrtoidine and myrtoidine
Kazerouni, Amaan M.,Mancheno, Danny E.,Blakey, Simon B.
, p. 389 - 403 (2019/08/01)
The Malagasy alkaloids, isolated in the 1990s from Madagascan shrub Strychnos myrtoides, are a family of strychnos alkaloids whose members have been reported to potentiate chloroquine activity against resistant strains of Plasmodium falciparum malaria. 11-Demethoxymyrtoidine, myrtoidine, and malagashanine were identified as the major components of the shrub used by local populations to treat malaria. Herein we report our studies on model systems to construct the EF dihydropyran lactone moiety present in 11-demethoxymyrtoidine and myrtoidine, and initial studies toward the application of these strategies to the total synthesis of these alkaloids.
Synthesis of 1-(n-hexyl-5-one)-2-chlorobenzimidazole
Dubey,Naidu,Anandam,Hemasunder
, p. 1239 - 1242 (2007/10/03)
o-Phenylenediamine on condensation with urea gives the known benzimidazolin-2-one, which on reaction with phosphoryl chloride in the presence of catalytic amount of phenol yields the already reported 2- chlorobenzimidazole. The latter on alkylation with 6-chloro-2-hexanone in the presence of K2CO3 in DMF medium, gives the title compound.
