5799-68-8

Basic information

• Product Name: methanedisulphonyl dichloride
• Synonyms: methanedisulphonyl dichloride;methanedisulfonyl chloride;methanedisulfonyl dichloride;methylenedisulfonyl dichloride;Methanedisulfonic acid dichloride;Methylenedisulfonyl Dichloride Methanedisulfonyl Chloride
• CAS NO: 5799-68-8
• Molecular Formula: CH₂Cl₂O₄S₂
• Molecular Weight: 213.06018
• EINECS: 227-350-9
• Mol File: 5799-68-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 138 °C / 15mmHg
• Flash Point: 137.9°C
• Appearance: /
• Density: 1.83
• Vapor Pressure: 0.00157mmHg at 25°C
• Refractive Index: 1.5140-1.5180
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: methanedisulphonyl dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: methanedisulphonyl dichloride(5799-68-8)
• EPA Substance Registry System: methanedisulphonyl dichloride(5799-68-8)

Safety Data

• RIDADR: 3265
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 5799-68-8(Hazardous Substances Data)

Usage

General Description

Methanedisulfonyl dichloride, commonly referred to as DSD Acid Chloride, possesses the molecular formula: CH2Cl2O4S2. This chemical compound primarily features two chloride groups and two sulfonic acid groups. The powerful and versatile reagent reacts readily with various types of nucleophiles. It's primarily used in the chemical industry for reactions like sulfonylation and cyclization. Extremely reactive, it must be handled with care due to its acid chloride and disulfonyl dichloride characteristics, as it can cause severe burns and eye damage.

InChI:InChI=1/CH2Cl2O4S2/c2-8(4,5)1-9(3,6)7/h1H2

Upstream product

• 503-40-2 methanedisulfonic acid 
• 64-19-7 acetic acid 
• 10026-13-8 phosphorus pentachloride 

Downstream Products

• 503-40-2 methanedisulfonic acid 
• 2396-53-4 di(2-phenylethyl) ether 
• 403-69-0 methanedisulfonic acid bis-(3-trifluoromethyl-anilide) 
• 77505-27-2 N,N'-diethyl-N,N'-diphenylmethionamide 
• 861355-35-3 N,N'-bis-(4-nitro-phenyl)-methanedisulfonamide 
• 85891-81-2 methanedisulfoanilide 
• 2997-54-8 diphenyl methylenedisulfonate 
• 5799-71-3 1,3-dichlorooctane 
• 5799-72-4 3-chloro-octanesulfonyl chloride 
• 124-63-0 methanesulfonyl chloride 
• 93437-19-5 Methandisulfonsaeure-bis-phenaethylamid 
• 93437-18-4 Methandisulfonsaeure-bis-<1-phenyl-aethylamid> 
• 92870-82-1 Methandisulfonsaeure-bis-benzylamid 
• 99871-35-9 Methandisulfonsaeure-bis-(5-nitro-2-methyl-anilid) 

Relevant articles and documents

Synthesis and biological evaluation of nonionic prenyl, geranyl, and farnesyl diphosphate surrogates

Prenyl, geranyl, and farnesyl derivatives containing nonionic surrogates for the diphosphate moiety, including disulfones 4-6 and 7-9, methylene disulfonamides 10-12, and carbamyl sulfamides 13-15, have been synthesized and evaluated biologically in an effort to find suitable nonlabile, neutral inhibitors for enzymatic reactions which use these isoprenoid diphosphates as substrates. Farnesyl derivatives 6, 9, 12, and 15 were ineffective as squalene synthase inhibitors in vitro. Compounds 4-15 were screened in human skin fibroblasts for their effects on fatty acid, cholesterol, and DNA synthesis. In general, compounds 10-15 showed more inhibition than 4-9 and had a greater effect on DNA synthesis than on lipid synthesis, with the exception of 15.