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58-25-3

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58-25-3 Usage

Chemical Properties

Pale Yellow Solid

Uses

Controlled substance (depressant). Anxiolytic. Prototype of the benzodiazepine anxiolytics

Definition

ChEBI: A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.

Therapeutic Function

Tranquilizer

Synthesis Reference(s)

The Journal of Organic Chemistry, 26, p. 1111, 1961 DOI: 10.1021/jo01063a034

Hazard

Anticonvulsant, sedative, and amnesic properties.

Metabolism

Chlordiazepoxide is well absorbed after oral administration, and peak blood concentration usually is reached in approximately 4 hours. Intramuscular absorption of chlordiazepoxide, however, is slower and erratic. The half-life of chlordiazepoxide is variable but usually quite long (6–30 hours). The initial N-demethylation product, N-desmethylchloridiazepoxide, undergoes deamination to form the demoxepam, which is extensively metabolized, and less than 1% of a dose of chlordiazepoxide is excreted as demoxepam. Demoxepam can undergo four different metabolic fates. Removal of the N-oxide moiety yields the active metabolite, N-desmethyldiazepam (desoxydemoxepam). This product is a metabolite of both chlordiazepoxide and diazepam and can be hydroxylated to yield oxazepam, another active metabolite that is rapidly glucuronidated and excreted in the urine. Another possibility for metabolism of demoxepam is hydrolysis to the “opened lactam,” which is inactive. The two other metabolites of demoxepam are the products of ring A hydroxylation (9-hydroxydemoxepam) or ring C hydroxylation (4′-hydroxydemoxepam), both of which are inactive.

Check Digit Verification of cas no

The CAS Registry Mumber 58-25-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 58-25:
(4*5)+(3*8)+(2*2)+(1*5)=53
53 % 10 = 3
So 58-25-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H14ClN3O/c1-18-15-10-20(21)16(11-5-3-2-4-6-11)13-9-12(17)7-8-14(13)19-15/h2-9,21H,10H2,1H3/p+1

58-25-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name chlordiazepoxide

1.2 Other means of identification

Product number -
Other names Solium

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:58-25-3 SDS

58-25-3Upstream product

58-25-3Relevant articles and documents

Heterocycles. IV. Reactions of 2 amino 3H 1,4 benzodiazepines with primary amines and hydroxylamines

Meguro,Natsugari,Tawada,Kuwada

, p. 2366 - 2374 (2007/10/05)

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