58008-15-4

Usage

Uses

Used in Pharmaceutical Industry:
(4-methoxyphenyl)-(4-methylpentanyl)amine is used as a potential active pharmaceutical ingredient for the development of new drugs due to its unique chemical structure and the presence of methoxy and methyl groups, which may contribute to its biological activity.
Used in Chemical Industry:
(4-methoxyphenyl)-(4-methylpentanyl)amine can be used as an intermediate in the synthesis of other organic compounds or as a reagent in various chemical reactions, given its amine functional group and the presence of methoxy and methyl groups.

Upstream product

• 56037-26-4 4-methoxy-N-(4-methylpentan-2-ylidene)aniline 
• 104-94-9 4-methoxy-aniline 
• 108-10-1 4-methyl-2-pentanone 
• 21020-27-9 4-methylpent-2-yne 

Downstream Products

• 1073339-61-3 (S)-4-methoxy-N-(4-methylpentan-2-yl)aniline 
• 1374002-63-7 (R)-4-methoxy-N-(4-methylpentan-2-yl)aniline 

Relevant academic research and scientific papers

Oxidative Kinetic Resolution of Acyclic Amines Based on Equilibrium Control

An oxidative kinetic resolution of racemic acyclic amines was developed using an imine derivative as the resolving reagent and chiral phosphoric acid as the catalyst to give enantiomers in good yields with high to excellent enantioselectivities. The key t

Improving C=N bond reductions with (Cyclopentadienone)iron complexes: Scope and limitations

Herein, we broaden the application scope of (cyclo-pentadienone)iron complexes 1 in C=N bond reduction. The catalytic scope of pre-catalyst 1b, which is more active than the “Kn?lker complex” (1a) and other members of its family, has been expanded to the catalytic transfer hydrogenation (CTH) of a wider range of aldimines and ketimines, either pre-isolated or generated in situ. The kinetics of 1b-promoted CTH of ketimine S1 were assessed, showing a pseudo-first order profile, with TOF = 6.07 h–1 at 50 % conversion. Moreover, the chiral complex 1c and its analog 1d were employed in the enantioselective reduction of ketimines and reductive amination of ketones, giving fair to good yields and moderate enantioselectivity.

Bis(amidate)bis(amido) titanium complex: A regioselective intermolecular alkyne hydroamination catalyst

An efficient and selective bis(amidate)bis(amido) titanium precatalyst for the anti-Markovnikov hydroamination of alkynes is reported. Hydroamination of terminal and internal alkynes with primary alkylamines, arylamines, and hydrazines is promoted by 5-10 mol % of Ti catalyst. Various functional groups are tolerated including esters, protected alcohols, and imines. The in situ generated complex shows comparable catalytic activity, demonstrating its synthetic versatility for benchtop application. Applications of this catalyst for the synthesis of amino alcohols and a one-pot procedure for indole synthesis are described. A mechanistic proposal that invokes turnover-limiting protonolysis is presented to rationalize the observed regioselectivities.

Enantioselective organocatalytic reductive amination of aliphatic ketones by benzothiazoline as hydrogen donor

The chiral phosphoric acid-catalyzed enantioselective reductive amination of aliphatic ketones with aromatic amines was successfully achieved by the use of benzothiazoline as the hydrogen donor. Corresponding chiral aliphatic amines were obtained with exc