58012-94-5Relevant academic research and scientific papers
Process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines which are useful as antihypertensive compounds, their separation into the respective optical antipodes, and the stereoisomeric compounds so obtained
-
, (2008/06/13)
A process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines, in the racemic form, of the formula STR1 in which: the pyridine ring is alpha-, beta-, or gamma-substituted; R=H; Cn H2n+1, n being in the range from 1 to 4; R'=H, halogen, CH3, OCH3, in which process: (a) pyridine aldehyde is reacted between -5° C. and 0° C. with (CH3)2 S=CH2 ; (b) the oxirane so obtained is treated with an arylpiperazine; (c) the hydroxyl derivative obtained in (b), after salification with alkaline hydrides or hydrates in a solvent medium is treated with alkylating agents, and the separation of the compounds so obtained into the respective optical antipodes.
