58013-09-5Relevant academic research and scientific papers
Resolution and pharmacological properties of the enantiomers of the potent α-adrenoceptor antagonist 1-[2-ethoxy-2-(3'-pyridyl)ethyl]-4-(2'-methoxy-phenyl)piperazine
Bonacchi,Agostini,Fedi,Bacciarelli,Boni,Castellucci,Perretti,Manzini
, p. 650 - 654 (2007/10/02)
Resolution of the optical isomers of the α-adrenoceptor antagonist IP-66 (1-[2-ethoxy-2-(3'-pyridyl)ethyl]-4-(2'-methoxy-phenyl)piperazine) and its intermediate IP-30 (1-[2-hydroxy-2-(3'-pyridyl)ethyl]-4-(2'-methoxy-phenyl)piperazine have been carried out
Process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines which are useful as antihypertensive compounds, their separation into the respective optical antipodes, and the stereoisomeric compounds so obtained
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, (2008/06/13)
A process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines, in the racemic form, of the formula STR1 in which: the pyridine ring is alpha-, beta-, or gamma-substituted; R=H; Cn H2n+1, n being in the range from 1 to 4; R'=H, halogen, CH3, OCH3, in which process: (a) pyridine aldehyde is reacted between -5° C. and 0° C. with (CH3)2 S=CH2 ; (b) the oxirane so obtained is treated with an arylpiperazine; (c) the hydroxyl derivative obtained in (b), after salification with alkaline hydrides or hydrates in a solvent medium is treated with alkylating agents, and the separation of the compounds so obtained into the respective optical antipodes.
