58014-99-6

Upstream product

• 100-10-7 4-dimethylamino-benzaldehyde 
• 107-15-3 ethylenediamine 
• 81512-54-1 N,N′‐bis(4‐dimethylamino)benzylidene‐ethane‐1,2‐diamine 

Downstream Products

• 1173912-71-4 N,N'-bis(4-dimethylaminobenzyl)imidazolinium chloride 

Relevant academic research and scientific papers

Platinum (II) N-heterocyclic carbene complexes: Synthesis, characterization and cytotoxic properties

Platinum (II) complexes bearing N-heterocyclic carbene (NHC) ligands have been widely used in catalytic chemistry, but there are very few reports of biological properties of this type of complexes. A series of [PtCl2(NHC)(PEt3)] comp

One-pot synthesis of imidazolinium salts via the ring opening of tetrahydrofuran

A new one-pot synthesis of C2-hydroxypropyl-substituted imidazolinium salts via the ring opening of tetrahydrofuran (THF) with N,N′-disubstituted diamines has been developed. Preliminary studies of the reaction mechanism suggest the CO2-promoted oxidative ring opening of THF followed by Hg(ii)-mediated oxidation of an imidazolidine intermediate. These novel C2-substituted imidazolinium salts have shown to be active catalysts for the aza-Diels-Alder reactions.

FBXO3 INHIBITORS

The present application discloses benzathine and related compounds and their use as FBXO-3 inhibitors.

Reversible aminal formation: Controlling the evaporation of bioactive volatiles by dynamic combinatorial/covalent chemistry

Dynamic mixtures generated by reversible aminal formation efficiently prolong the duration of evaporation of bioactive volatile aldehydes. Secondary diamines used for the generation of dynamic mixtures are obtained by treatment of primary diamines with carbonyl compounds and reduction of the diimines with NaBH4. The reversibilities of the reactions were demonstrated by NMR measurements in buffered aqueous solutions. Kinetic rate constants and equilibrium constants for the formation and hydrolysis of aminals were determined. The performance of dynamic mixtures as delivery systems for perfumery ingredients was tested after deposition onto cotton, and the long-lastingness of fragrance evaporation was investigated by dynamic headspace analysis against a reference sample. The simplicity of the concept together with its excellent performance makes this delivery system highly interesting for applied perfumery. Reversible aminal formation might also be successfully applicable to dynamic combinatorial/covalent chemistry for screening of pharmaceutically or catalytically active ligands and receptors. The evaporation of bioactive volatiles that are emitted from flowers to attract insects and that are used as fragrances in our everyday life is limited in time. Dynamic mixtures obtained by reversible aminal formation of suitably designed diamines with volatile aldehydes prolong the perception of these compounds in functional perfumery.

Synthesis of [N, N'-Bis(5-benzoyl-4-phenylthiazol-2-yl)-N, N-bisbenzyl]ethane-1, 2-diamines

Synthesis of [N,N'-bis(N-benzoylthiocarbamoyl)-N,N'-bis(benzyl)]ethane-1,2- diamines 4a-h, their cyclization to [N,N'-bis(5-benzoyl-4-phenylthiazol-2-yl)-N, N'-bisbenzyl]ethane-1,2-diamines 5a-h by reaction with phenacyl bromide and the results of antibacterial activity assay of 4a-h and 5a-h are reported.

CONTROLLED RELEASE OF ACTIVE ALDEHYDES AND KETONES FROM EQUILIBRATED DYNAMIC MIXTURES

The present invention concerns a dynamic mixture obtained by combining, in the presence of water, at least one diamine derivative, comprising at least one benzylamine moiety, with at least one active aldehyde or ketone. The invention's mixture is capable of releasing in a controlled and prolonged manner said active compound, in particular perfuming ingredients, in the surrounding environment.

Tetrahydroimidazoles - A promising group of expected NSAIDS - Their synthesis and anti-inflammatory activity

Several new 1, 2, 3-trisubstituted tetrahydroimidazoles (11-28) have been synthesised and their structures elucidated on the basis of spectral data. These compounds show promising anti-inflammatory activity by carrageenin induced paw edema test in rats and few of them showed an activity better than indomethacin.

Synthesis of novel tetrahydroimidazole derivatives and studies for their biological properties

Ethylenediamine was reacted with suitable aromatic aldehydes in order to prepare their respective diSchiff bases. These compounds were then reduced to give the corresponding tetrahydrodiSchiff bases, which were low melting in nature. Finally, these derivatives were condensed with different aromatic aldehydes to give the desired tetrahydroimidazoles. The structures of all these compounds were established on the basis of spectral data. These novel tetrahydroimidazoles showed promising anti-inflammatory and analgesic activity. The compounds were also screened for their anti-bacterial property against Staphylococcus aureus and Escherichia coli.