58016-39-0Relevant academic research and scientific papers
Zn(OTf)2-Catalyzed Phosphinylation of Propargylic Alcohols: Access to γ-Ketophosphine Oxides
Shan, Changkai,Chen, Fushan,Pan, Jiaoting,Gao, Yuxing,Xu, Pengxiang,Zhao, Yufen
, p. 11659 - 11666 (2017/11/10)
The first facile and efficient Zn(OTf)2-catalyzed direct coupling of unprotected propargylic alcohols with arylphosphine oxides has been developed, affording a general, one-step approach to access structurally diverse γ-ketophosphine oxides via sequential Meyer-Schuster rearrangement/phospha-Michael reaction along with new C(sp3) - P and C=O bond formations, operational simplicity, and complete atom economy under ligand-free and base-free conditions.
