58020-38-5Relevant academic research and scientific papers
8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE
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Page/Page column 53, (2012/09/11)
Disclosed is a compound represented by formula (1) or a pharmacologically acceptable salt thereof (In the formula, A represents a group that is represented by formula (A-1); R1a and R1b may be the same or different and each independently represents a C1-6 alkyl group which may be substituted by one to three halogen atoms; m and n each independently represents an integer of 0-5; X1 represents a hydroxyl group or an aminocarbonyl group; Z1 represents a single bond or the like; and R2 represents an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group or the like.)
Facile p-toluenesulfonic acid-promoted para-selective monobromination and chlorination of phenol and analogues
Bovonsombat, Pakorn,Ali, Rameez,Khan, Chiraphorn,Leykajarakul, Juthamard,Pla-On, Kawin,Aphimanchindakul, Suraj,Pungcharoenpong, Natchapon,Timsuea, Nisit,Arunrat, Anchalee,Punpongjareorn, Napat
experimental part, p. 6928 - 6935 (2010/10/01)
para-Regioselective bromination of phenol and analogues, promoted by p-toluenesulfonic acid, is achieved in high to excellent yields at room temperature with N-bromosuccinimide. Chlorination with N-chlorosuccinimide and catalysed by p-toluenesulfonic acid also gives para-chlorinated phenol analogues in good yields at room temperature. para-Bromination of phenol, promoted by p-toluenesulfonic acid, is achieved in excellent yields at room temperature with N-bromosuccinimide. p-Toluenesulfonic acid is also effective as a promoter of para-chlorination with N-chlorosuccinimide.
