1-(2-Chloro-5-hydroxyphenyl)ethan-1-one

Base Information

Chemical Name:1-(2-Chloro-5-hydroxyphenyl)ethan-1-one
CAS No.:58020-38-5
Molecular Formula:C8H7ClO2
Molecular Weight:170.595
Hs Code.:
DSSTox Substance ID:DTXSID60499274
Wikidata:Q82349907

Synonyms:58020-38-5;1-(2-Chloro-5-hydroxyphenyl)ethan-1-one;1-(2-Chloro-5-hydroxyphenyl)ethanone;2'-CHLORO-5'-HYDROXYACETOPHENONE;MFCD18393141;Ethanone, 1-(2-chloro-5-hydroxyphenyl)-;SCHEMBL7306944;DTXSID60499274;AKOS016354437;NS-01396

Suppliers and Price of 1-(2-Chloro-5-hydroxyphenyl)ethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 1-(2-Chloro-5-hydroxyphenyl)ethan-1-one

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:170.0134572
Heavy Atom Count:11
Complexity:158

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1=C(C=CC(=C1)O)Cl

Technology Process of 1-(2-Chloro-5-hydroxyphenyl)ethan-1-one

There total 3 articles about 1-(2-Chloro-5-hydroxyphenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 121-71-1
3-Hydroxyacetophenone

: 58020-38-5
3-acetyl-4-chlorophenol

: 69240-96-6
1-(2-chloro-3-hydroxyphenyl)ethanone

: 61124-56-9
4'-chloro-3'-hydroxyacetophenone

Guidance literature:: 3-Hydroxyacetophenone; With toluene-4-sulfonic acid; In water; acetonitrile; at 20 ℃; for 0.0833333h;

With N-chloro-succinimide; In water; acetonitrile; at 20 ℃; for 2h; regioselective reaction;
DOI:10.1016/j.tet.2010.06.041

Reference yield:

: 77344-69-5
5-methoxy-o-chloroacetophenone

: 58020-38-5
3-acetyl-4-chlorophenol

Guidance literature:: 5-methoxy-o-chloroacetophenone; With aluminum (III) chloride; In chlorobenzene; at 120 ℃; for 0.5h;

With hydrogenchloride; In water; chlorobenzene;

Reference yield:

: 6280-89-3
2-chloro-5-methoxybenzoic acid

: 58020-38-5
3-acetyl-4-chlorophenol

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether; tetrahydrofuran / -78 - 20 °C

2: aluminum (III) chloride / chlorobenzene / 0.5 h / 120 °C

With aluminum (III) chloride; In tetrahydrofuran; diethyl ether; chlorobenzene;