58029-73-5Relevant academic research and scientific papers
Metal free biomimetic deaminative direct C-C coupling of unprotected primary amines with active methylene compounds
Ghosh, Santanu,Jana, Chandan K.
supporting information, p. 10153 - 10157 (2019/12/26)
An unprecedented direct C-C coupling reaction of unprotected primary amines with active methylene compounds is reported. The reaction involves a biomimetic deamination of amines which was achieved under conditions free of metallic reagents and strong oxidizing agents. A wide range of primary amines was reacted with different active methylene compounds to provide structurally diverse trisubstituted alkenes and dihydropyridines. A kinetic study revealed an activation barrier of 10.1 kcal mol-1 for the conversion of a key intermediate of the reaction.
Diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivative for inducing cell apoptosis, a method for producing the same, and an anticancer drug containing the same
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Paragraph 0133-0136; 0146-0147; 0158-0159, (2019/04/05)
The present invention relates to a diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate derivative which induces cell apoptosis, a method of manufacturing the same, and an anti-cancer drug containing the same. A compound represented by chemical form
