58046-50-7

Usage

Uses

Used in Coordination Chemistry:
AHPC is used as a ligand for [coordination with metal ions] due to [its ability to form stable complexes, enhancing the properties of metal-based compounds].
Used in Pharmaceutical Applications:
5-amino-1-(2-hydroxyethyl)pyrazole-4-carboxylic acid is used as a potential drug candidate for [treatment of various diseases] because of [its unique chemical structure and potential for biological activity].
Used in Organic Synthesis:
AHPC is used as a building block in [organic synthesis] for [creating new compounds with specific properties, leveraging its reactivity and functional groups].
Used in Material Science:
5-amino-1-(2-hydroxyethyl)pyrazole-4-carboxylic acid is used as a component in [development of new materials] for [its potential to contribute to material properties such as conductivity, stability, or reactivity].
Used as a Chelating Agent:
AHPC is used as a chelating agent for [binding and stabilizing metal ions] in various applications, including [improving the solubility or reactivity of metal ions in chemical processes].

InChI:InChI=1/C6H9N3O3/c7-5-4(6(11)12)3-8-9(5)1-2-10/h3,10H,1-2,7H2,(H,11,12)

Upstream product

• 109-84-2 2-hydroxyethylhydrazine 
• 1187-27-5 2-cyano-3-dimethylamino acrylate 
• 16849-87-9 2-(4b-dimethylaminomethylene)-2-cyano ethyl acetate 

Downstream Products

• 73616-27-0 5-amino-1-(2-hydroxyethyl)-1H-pyrazole 

Relevant academic research and scientific papers

Synthesis method of N-hydroxyethyl-5-amino-1H pyrazole

The invention discloses a synthesis method of N-hydroxyethyl-5-amino-1H pyrazole. The synthesis method comprises the following steps: by taking N, N-dimethylformamide as a raw material, carrying out one-pot reaction on the N, N-dimethylformamide, dimethyl sulfate and cyanoacetic acid R ester to prepare 2-cyano-3-(dimethylamino) acrylic acid R ester; carrying out cyclization and hydrolysis on the 2-cyano-3-(dimethylamino) acrylic acid R ester and beta-hydroxyethylhydrazine to prepare N-hydroxyethyl-5-amino-1H pyrazole-4-formic acid; and carrying out decarboxylation on N-hydroxyethyl-5-amino-1H pyrazole-4-formic acid, so as to prepare N-hydroxyethyl-5-amino-1H pyrazole, wherein R is an alkane group below C4. The synthesis method provided by the invention has the advantages of strong operability, high economic benefit and high yield.

Preparation of 4,5-diamino-1-(2'-hydroxyethyl)-pyradazole and acid addition salts thereof

Disclosed is an improved process for the preparation of 4,5-diamino-1-(2'-hydroxyethyl)pyrazole and acid addition salts thereof such as the addition salt from sulfuric acid. The process comprises a novel combination of steps beginning with an alkyl (alkoxymethylene)cyanoacetate and 2-hydroxyethylhydrazine and the formation of intermediate compounds 5-amino-4-alkoxycarbonyl-1-(2'-hydroxyethyl)pyrazole (I), 5-amino-4-carboxyl-1-(2'-hydroxyethyl)pyrazole (II), 5-amino-1-(2'-hydroxyethyl)pyrazole (III), 5-amino-1-(2'-hydroxyethyl)4-nitrosopyrazole (IV),

Preparation of 4,5-diamino-1-(2′-hydroxyethyl)-pyrazole and acid addition salts thereof

Disclosed is an improved process for the preparation of 4,5-diamino-1-(2′-hydroxyethyl)pyrazole and acid addition salts thereof such as the addition salt from sulfuric acid. The process comprises a novel combination of steps beginning with an alkyl(alkoxymethylene)cyanoacetate and 2-hydroxyethylhydrazine and the formation of intermediate compounds 5-amino-4-alkoxycarbonyl-1-(2′-hydroxyethyl)pyrazole (I), 5-amino-4-carboxyl-1-(2′-hydroxyethyl)pyrazole (II), 5-amino-1-(2′-hydroxyethyl)pyrazole (III), 5-amino-1-(2′-hydroxyethyl)4-nitrosopyrazole (IV).