73616-27-0

Basic information

• Product Name: 5-Amino-1-(2-hydroxyethyl)pyrazole
• Synonyms: 5-AMINO-1-(2-HYDROXYETHYL)PYRAZOLE;2-(5-Amino-1H-pyrazol-1-yl)ethanol;5-amino-1-(2-hydroethyl)pyrazole;5-AMINO-1H-PYRAZOLE-1-ETHANOL;5-Amino-1-(2-hydroxyethyl)pyrazol;5-Amino-1-hydroxyethylpyrazole;5-Amino-1-(beta-hydroxyethyl)pyrazole;5-Amino-1-(2-hydroxy
• CAS NO: 73616-27-0
• Molecular Formula: C₅H₉N₃O
• Molecular Weight: 127.14
• Mol File: 73616-27-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 107.0 to 109.0 °C
• Boiling Point: 140°C/0.04mmHg(lit.)
• Flash Point: 158.2 °C
• Appearance: /Solid
• Density: 1.35 g/cm³
• Vapor Pressure: 3.97E-05mmHg at 25°C
• Refractive Index: 1.616
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.42±0.10(Predicted)
• CAS DataBase Reference: 5-Amino-1-(2-hydroxyethyl)pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-1-(2-hydroxyethyl)pyrazole(73616-27-0)
• EPA Substance Registry System: 5-Amino-1-(2-hydroxyethyl)pyrazole(73616-27-0)

Safety Data

• Hazardous Substances Data: 73616-27-0(Hazardous Substances Data)

Usage

General Description

5-Amino-1-(2-hydroxyethyl)pyrazole is a chemical compound that belongs to the class of organic compounds known as pyrazoles. Pyrazoles are compounds containing a pyrazole ring, which is a five-membered aromatic ring with two nitrogen atoms at positions 1 and 2, and three carbon atoms. In the structure of 5-Amino-1-(2-hydroxyethyl)pyrazole, there’s an amino functional group at position 5 on the pyrazole ring and a 2-hydroxyethyl group attached to position 1. The details about its properties such as melting point, boiling point or toxicity are not widely available, suggesting its limited use or recent discovery. Its application in industry or research fields remain relatively unknown, requiring further studies to understand its full potential and safety.

InChI:InChI=1/C5H9N3O/c6-5-1-2-7-8(5)3-4-9/h1-2,9H,3-4,6H2

Upstream product

• 58046-50-7 N-hydroxyethyl-5-amino-1H-pyrazole-4-carboxylic acid 
• 109-84-2 2-hydroxyethylhydrazine 
• 6162-76-1 cyanoacetaldehyde 

Downstream Products

• 176326-65-1 2-[5-(tritylamino)-1H-pyrazol-1-yl]ethanol 
• 116856-18-9 5-formamido-1-(2-formyloxyethyl)pyrazole 

Relevant articles and documents

Synthesis method of N-hydroxyethyl-5-amino-1H pyrazole

The invention discloses a synthesis method of N-hydroxyethyl-5-amino-1H pyrazole. The synthesis method comprises the following steps: by taking N, N-dimethylformamide as a raw material, carrying out one-pot reaction on the N, N-dimethylformamide, dimethyl sulfate and cyanoacetic acid R ester to prepare 2-cyano-3-(dimethylamino) acrylic acid R ester; carrying out cyclization and hydrolysis on the 2-cyano-3-(dimethylamino) acrylic acid R ester and beta-hydroxyethylhydrazine to prepare N-hydroxyethyl-5-amino-1H pyrazole-4-formic acid; and carrying out decarboxylation on N-hydroxyethyl-5-amino-1H pyrazole-4-formic acid, so as to prepare N-hydroxyethyl-5-amino-1H pyrazole, wherein R is an alkane group below C4. The synthesis method provided by the invention has the advantages of strong operability, high economic benefit and high yield.

Cyanoacetaldehyde - New Synthetic Applications of an Old Compound Syntheses with Nitriles, XCI

Various reactions of cyanoacetaldehyde (1), freshly prepared by ozonization of (E)-1,4-dicyano-2-butene or allylcyanide, are described.Thus, conversion of 1 with anilines gave β-phenylaminoacrylonitriles 2a-e.Reaction of 1 with hydrazines led to the corresponding hydrazones 3a-e, which could be cyclized under alkaline conditions to 5-aminopyrazoles 4a-d.An aldol-type condensation product 5a could be obtained by reaction of 1 with sodiumphenoxide.Treatment of 1 with dimethylformamide-dimethylacetal led to the formation of (E)-3-dimethylamino-2-formylpropenenitrile (6), a very useful synthon in synthetic chemistry.For the determination of the structure of 6 the method of steady state diffferential NOEs was used.Reaction of 6 with hydrazines gave 1-substituted-4-cyanopyrazoles 7a-k. Keywords.Cyanoacetaldehyde; Hydrazones; Cyanopyrazoles; Aminopyrazoles.