58076-32-7

Basic information

• Product Name: Benzenesulfonyl chloride, 4-propoxy-
• Synonyms: Benzenesulfonyl chloride, 4-propoxy-
• CAS NO: 58076-32-7
• Molecular Formula: C₉H₁₁ClO₃S
• Molecular Weight: 234.69984
• Mol File: 58076-32-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenesulfonyl chloride, 4-propoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonyl chloride, 4-propoxy-(58076-32-7)
• EPA Substance Registry System: Benzenesulfonyl chloride, 4-propoxy-(58076-32-7)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 58076-32-7(Hazardous Substances Data)

Usage

General Description

Benzenesulfonyl chloride, 4-propoxy- is an organic compound with the chemical formula C9H11ClO3S. It is a derivative of benzenesulfonyl chloride, which is a widely used reagent in organic synthesis. The addition of a propoxy group to the benzene ring results in the formation of 4-propoxy-benzenesulfonyl chloride. Benzenesulfonyl chloride, 4-propoxy- is typically used as a reagent in reactions that involve the substitution or functionalization of organic compounds. It is a versatile compound that finds application in the pharmaceutical, agrochemical, and material science industries. Additionally, it is also used in the production of specialty chemicals and in the synthesis of complex organic molecules.

Upstream product

• 622-85-5 propoxybenzene 
• 825-90-1 sodium p-hydroxybenzenesulfonate 
• 7790-94-5 chlorosulfonic acid 
• 108-95-2 phenol 
• 139-02-6 sodium phenoxide 

Downstream Products

• 105434-89-7 5-Fluoro-1-(4-propoxy-benzenesulfonyl)-1H-pyrimidine-2,4-dione 
• 105411-93-6 5-Bromo-1-(4-propoxy-benzenesulfonyl)-1H-pyrimidine-2,4-dione 
• 927636-57-5 N-isopropyl-4-propoxybenzenesulfonamide 
• 500015-59-8 N,N-diethyl-4-propoxybenzenesulfonamide 
• 24924-81-0 4-Propoxy-benzolsulfonsaeure-hydrazid 
• 1135-01-9 4-n-propoxybenzenesulfonamide 
• 107924-00-5 1-(4-propoxy-benzenesulfonyl)-piperidine 

Relevant articles and documents

N-ARYL SULFONAMIDE DERIVATIVES AS VACCINE ADJUVANT

Bis-aryl sulfonamide compounds and methods of using those compounds, e.g., in a method of enhancing or prolonging an immune response, are provided. For example, the compounds may be employed with a vaccine and optionally at least one other adjuvant and/or one or more TLR ligands, at least one MAP kinase inhibitor, or any combination thereof.

Synthesis and insecticidal activity in vitro and vivo of novel benzenesulfonyl derivatives based on potent target subunit H of V-ATPase

Two lead compounds with benzenesulfonamide were found through virtual screening based on the 3D structure of the subunit H of V-ATPase in previous study. 74 benzenesulfonyl derivatives were synthesized and their insecticidal activities were evaluated. The derivatives with propargyl substituents exhibit excellent insecticidal activities against Mythimna separata Walker. The LD50 values of compounds A5.7 (28.0 μg·g?1) and B5.7 (36.4 μg·g?1) were significantly less than that of Celangulin V (344.0 μg·g?1). Furthermore, Isothermal Titration Calorimetry (ITC) data indicate there is a strong binding affinity between A5.7 and V-ATPase Subunit H. These results demonstrate that it is a practical way to develop pesticides targeting at H subunit of V-ATPase.

NOVEL SEMI-SYNTHETIC GLYCOPEPTIDES AS ANTIBACTERIAL AGENTS

Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of the a glycopeptide (Compound A, Compound B, Compound H or Compound C) or the monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; conversion of the amide group in amino acid-3 on these scaffolds to various acylamide, acylsulfonamide, acylsulfonylurea derivatives; aminomethylation with substituent containing sulfonamide or acylsulfonamide group on amino acid-7 through Mannich reaction; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.