58083-59-3

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
6-Chloroisoindolin-1-one serves as a crucial building block in the synthesis of a wide range of pharmaceuticals and agrochemicals. Its ability to modulate biological processes and interact with proteins and enzymes makes it a valuable component in the development of new drugs and agricultural products.
Used in Dyes and Pigments Industry:
As an intermediate in the preparation of dyes and pigments, 6-Chloroisoindolin-1-one plays a significant role in the production of various colorants used across different industries, including textiles, plastics, and printing inks.
Used in Medicinal Chemistry Research:
6-CHLOROISOINDOLIN-1-ONE's potential applications in the field of medicinal chemistry are attributed to its capacity to influence biological processes and interact with proteins and enzymes. This makes 6-Chloroisoindolin-1-one a versatile chemical with diverse industrial and scientific applications, particularly in the discovery and development of novel therapeutic agents.

Upstream product

• 46234-01-9 N-(4′-chlorobenzyl)-2-methylpropan-2-amine 
• 77250-71-6 picolinic acid 4-chlorobenzylamide 
• 1972-28-7 diethylazodicarboxylate 
• 201230-82-2 carbon monoxide 
• 104-86-9 4-chlorobenzylamine 
• 439117-38-1 methyl 5-chloro-2-cyanobenzoate 
• 494210-98-9 methyl 5-chloro-2-[((trifluoromethyl)sulfonyl)oxy]benzoate 
• 27007-53-0 methyl-2-bromo-5-chlorobenzoate 

Downstream Products

• 1263311-29-0 C₁₈H₁₆ClNO₃ 

Relevant academic research and scientific papers

Palladium-Catalyzed Direct C-H Carbonylation of Free Primary Benzylamines: A Synthesis of Benzolactams

A protocol for palladium-catalyzed C-H carbonylation of readily available free primary benzylamines using NH2 as the chelating group under an atmospheric pressure of CO has been achieved, providing a general, atom- and step-economic approach to

Traceless Directing Group Assisted Cobalt-Catalyzed C?H Carbonylation of Benzylamines

The first example of cobalt-catalyzed C(sp2)?H carbonylation of benzylamines using a traceless directing group is reported, which was successfully applied to the synthesis of N?unprotected iso-indolinones through direct C?H/N?H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)-garenoxacin. (Figure presented.).

Convenient access to isoindolinones via carbamoyl radical cyclization. Synthesis of cichorine and 4-hydroxyisoindolin-1-one natural products

An efficient and convenient access to 2-tert-butylisoindolin-1-ones via an oxidative radical cyclization process from stable carbamoylxanthates, derived from secondary tert-butylamines, is described. The proposed mechanism for this transformation involves, the generation of a carbamoyl radical, its cyclization to the aromatic system, and the dilauroyl peroxide (DLP) mediated rearomatization to generate the isoindolinone ring system. Additionally, the syntheses of cichorine and 4-hydroxyisoindolin-1-one natural products were carried out to underscore the synthetic potential of this xanthate-based carbamoyl radical-oxidative cyclization.

Carbamoyl radicals from carbamoylxanthates: a facile entry into isoindolin-1-ones

It has been found that carbamoylxanthates derived from secondary t-butyl amines are stable compounds which function as efficient sources of carbamoyl radicals. The carbamoylxanthates derived from t-butylbenzylamines can be efficiently transformed into 2-t

THERAPEUTIC USE OF ARYL AMINO ACID DERIVATIVES

The compounds of formula (I) are useful in the treatment of faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, neuropathic pain, neuropathological disorders and sleep disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included.

Stereoselective synthesis of a potent thrombin inhibitor by a novel P2-P3 lactone ring opening

The concise synthesis of a potent thrombin inhibitor was accomplished by a mild lactone aminolysis between an orthogonally protected bis-benzylic amine and a diastereomerically pure lactone. The lactone was synthesized by the condensation of L-proline met