5809-38-1

Usage

Chemical Family

1H-Pyrazole

Structure

Pyrazole ring with methyl and nitro substituents, and a phenyl group

Common Uses

Chemical research, pharmaceutical development, synthesis of organic substances and materials

Potential Properties

Biological activities, pharmacological properties, versatile reactivity, and functional groups

Safety Precautions

Handle with care, follow proper safety protocols, potential hazards and toxic properties.

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 100-63-0 phenylhydrazine 
• 1131-16-4 3,5-dimethyl-1-phenyl-1H-pyrazole 
• 715-99-1 1-phenyl-3,5-dimethyl-4-nitrosopyrazole 
• 917-64-6 methyl magnesium iodide 
• 90946-24-0 3-methyl-4-nitro-1-phenyl-1H-pyrazole 
• 7697-37-2 nitric acid 
• 59-88-1 phenylhydrazine hydrochloride 
• 29917-12-2 Isonitrosoacetylacetone 
• 14531-55-6 3,5-dimethyl-4-nitro-1H-pyrazole 
• 6293-66-9 diphenyliodonium p-toluenesulfonate 
• 591-50-4 iodobenzene 
• 67-51-6 3,5-dimethyl-1H-pyrazole 

Downstream Products

• 128370-73-0 C₂₇H₂₄N₆O₅ 
• 128370-72-9 C₂₇H₂₄N₆O₄S 
• 128370-74-1 C₃₀H₂₆N₆O₆ 
• 129226-60-4 3-(4-Chloro-phenyl)-4-(5-methyl-4-nitro-2-phenyl-2H-pyrazol-3-yl)-1-phenyl-butan-1-one 
• 129242-80-4 4-(5-Methyl-4-nitro-2-phenyl-2H-pyrazol-3-yl)-1-phenyl-3-p-tolyl-butan-1-one 
• 129226-63-7 3-(4-Methoxy-phenyl)-4-(5-methyl-4-nitro-2-phenyl-2H-pyrazol-3-yl)-1-phenyl-butan-1-one 
• 129226-62-6 3-(2,6-Dichloro-phenyl)-4-(5-methyl-4-nitro-2-phenyl-2H-pyrazol-3-yl)-1-phenyl-butan-1-one 
• 128370-71-8 C₃₀H₂₈N₆O₄ 
• 128370-63-8 C₂₉H₂₅ClN₆O₄ 
• 128370-65-0 C₂₉H₂₄Cl₂N₆O₄ 
• 128370-68-3 4-[2-(5-Methyl-4-nitro-2-phenyl-2H-pyrazol-3-yl)-1-(5-methyl-4-nitro-2-phenyl-2H-pyrazol-3-ylmethyl)-ethyl]-phenol 
• 128370-75-2 C₃₀H₂₈N₆O₅ 
• 128370-66-1 2-[2-(5-Methyl-4-nitro-2-phenyl-2H-pyrazol-3-yl)-1-(5-methyl-4-nitro-2-phenyl-2H-pyrazol-3-ylmethyl)-ethyl]-phenol 
• 128370-64-9 C₂₉H₂₄Cl₂N₆O₄ 

Relevant academic research and scientific papers

Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity

Kallikrein-related peptidase 6 (KLK6) is a secreted serine protease that belongs to the family of tissue kallikreins (KLKs). Many KLKs are investigated as potential biomarkers for cancer as well as therapeutic drug targets for a number of pathologies. KLK6, in particular, has been implicated in neurodegenerative diseases and cancer, but target validation has been hampered by a lack of selective inhibitors. This work introduces a class of depsipeptidic KLK6 inhibitors, discovered via high-throughput screening, which were found to function as substrate mimics that transiently acylate the catalytic serine of KLK6. Detailed structure-activity relationship studies, aided by in silico modeling, uncovered strict structural requirements for potency, stability, and acyl-enzyme complex half-life. An optimized scaffold, DKFZ-251, demonstrated good selectivity for KLK6 compared to other KLKs, and on-target activity in a cellular assay. Moreover, DKFZ-633, an inhibitor-derived activity-based probe, could be used to pull down active endogenous KLK6.

CHEMICAL SUBSTANCES WHICH INHIBIT THE ENZYMATIC ACTIVITY OF HUMAN KALLIKREIN-RELATED PEPTIDASE 6 (KLK6)

The invention relates to compounds which are suitable for the treatment of a disease associated with kallikrein-like peptidase 6 overexpression and to pharmaceutical compositions containing such compounds. The invention further relates to a kit of parts comprising such compounds or pharmaceutical compositions.

Regioselective N-arylation of nitroazoles. Determination of the structure of N-arylnitro-azoles on the basis of NMR spectroscopic data and quantum-chemical calculations

The N-arylation of a series of nitroazoles has been studied with the aid of diaryliodonium salts in the presence of CuI under the action of microwave radiation. It was found that alkylation proceeds regioselectively in each actual case with the formation

Reactions of pyrazoles and pyrazolium salts with complex metal hydrides and organometallic reagents. Synthesis of pyrazolines and pyrazolidines

2-Pyrazolin-4-oximes have been synthesized by reaction of 4-nitroso- and 4-nitropyrazoles with complex metal hydrides and organometallic reagents. Furthermore, 4-nitropyrazolium tetrafluoroborates are reactive substrates towards organolithium and Grignard