58101-23-8

Basic information

• Product Name: ETHYL 2,4-DIFLUOROBENZOYLACETATE
• Synonyms: ETHYL 3-(2,4-DIFLUOROPHENYL)-3-OXOPROPANOATE;ETHYL 2,4-DIFLUOROBENZOYLACETATE;3-(2,4-DIFLUOROPHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER;Benzenepropanoic acid, 2,4-difluoro-b-oxo-, ethyl ester;ETHYL-(2,4-DIFLUOROPHENYL)-3-OXOPROPANOATE
• CAS NO: 58101-23-8
• Molecular Formula: C₁₁H₁₀F₂O₃
• Molecular Weight: 228.19
• Mol File: 58101-23-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 74-78°C/0.23mm
• Flash Point: 117.1 °C
• Appearance: /
• Density: 1.251 g/cm³
• Vapor Pressure: 0.00492mmHg at 25°C
• Refractive Index: 1.481
• PKA: 10.00±0.48(Predicted)
• CAS DataBase Reference: ETHYL 2,4-DIFLUOROBENZOYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DIFLUOROBENZOYLACETATE(58101-23-8)
• EPA Substance Registry System: ETHYL 2,4-DIFLUOROBENZOYLACETATE(58101-23-8)

Safety Data

• Hazardous Substances Data: 58101-23-8(Hazardous Substances Data)

Usage

General Description

Ethyl 2,4-difluorobenzoylacetate is a chemical compound with the molecular formula C11H11F2O3. It is a synthetic organic compound that is commonly used in the field of pharmaceuticals and agrochemicals. ETHYL 2,4-DIFLUOROBENZOYLACETATE is commonly used as an intermediate in the synthesis of various pharmaceutical compounds and is also utilized as a building block for the synthesis of agrochemicals. It is a colorless liquid with a mildly sweet aroma and is typically stored and handled in a controlled environment due to its flammability and potential health hazards. The compound is also known by the trade names of 2,4-Difluorobenzoylacetate ethyl ester and ethyl 2,4-difluorophenylglyoxylate.

InChI:InChI=1/C11H10F2O3/c1-2-16-11(15)6-10(14)8-4-3-7(12)5-9(8)13/h3-5H,2,6H2,1H3

Upstream product

• 6148-64-7 ethyl potassium malonate 
• 1583-58-0 2,4-difluoro-benzoic acid 
• 72482-64-5 2,4-difluorobenzoyl chloride 
• 64-17-5 ethanol 
• 1404449-01-9 5-(2,4-difluorobenzoyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 188394-40-3 diethyl (2,4-difluorobenzoyl)malonate 

Relevant articles and documents

Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone

Fluoroquinolones substituted with N-1 biphenyl and napthyl groups were discovered to act as catalytically inhibitors of human topoisomerases I and II, and to possess anti-proliferative activity in vivo. Structural requirements for these novel quinolones t

Synthesis and antitumor activity of novel 4-(2-fluorophenoxy)quinoline derivatives bearing the 4-Oxo-1,4-dihydroquinoline-3-carboxamide moiety

A series of 4-(2-fluorophenoxy)quinoline derivatives bearing the 4-oxo-1,4-dihydroquinoline-3-carboxamide moiety were designed, synthesized, and evaluated for their in vitro antitumor activity against the H460, HT-29, MKN-45, U87MG, and SMMC-7721 cancer cell lines. Most of the tested compounds showed potent activity and high selectivity toward the HT-29 and MKN-45 cell lines. Furthermore, compounds 21b, 21c, and 21i were further examined for their c-Met kinase activity and exhibited strong efficacy with IC50 values in the single-digit nanomolar range, which was comparable with the positive control foretinib. The most promising compound 21c showed excellent cytostatic activity with IC50 values from 0.01 to 0.53 μM against all tested cell lines, thus being 1.7-2.2 times more active than foretinib. Novel 4-(2-fluorophenoxy)quinoline derivatives bearing the 4-oxo-1,4-dihydroquinoline- 3-carboxamide moiety were evaluated for their in vitro antitumor activity against several cancer cell lines. Compounds 21b, 21c, and 21i were also examined for their c-Met kinase activity in comparison to foretinib. Compound 21c showed excellent cytostatic activity with IC50 values from 0.01 to 0.53 μM against all tested cell lines and higher activity than foretinib.

Quinolone- and naphthyridonecarboxylic acid derivatives

The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which have hydrogen in the 6-position, to processes for their preparation, and to antibacterial compositions and feed additives containing them.